Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712082..712707 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MUW68_RS03235 Protein ID WP_003403218.1
Coordinates 712306..712707 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MUW68_RS03230 Protein ID WP_003403213.1
Coordinates 712082..712309 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03205 (MUW68_03205) 707261..707482 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MUW68_RS03210 (MUW68_03210) 707624..708229 + 606 WP_003898526.1 hypothetical protein -
MUW68_RS03215 (MUW68_03215) 708248..710815 - 2568 WP_244733040.1 SEC-C metal-binding domain-containing protein -
MUW68_RS03220 (MUW68_03220) 710899..711648 + 750 WP_003898528.1 hypothetical protein -
MUW68_RS03225 (MUW68_03225) 711645..711887 + 243 WP_003403210.1 hypothetical protein -
MUW68_RS03230 (MUW68_03230) 712082..712309 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MUW68_RS03235 (MUW68_03235) 712306..712707 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MUW68_RS03240 (MUW68_03240) 712836..712919 + 84 Protein_643 galactose-1-phosphate uridylyltransferase -
MUW68_RS03245 (MUW68_03245) 712938..714019 + 1082 Protein_644 galactose-1-phosphate uridylyltransferase -
MUW68_RS03250 (MUW68_03250) 714016..715107 + 1092 WP_003900977.1 galactokinase -
MUW68_RS03255 (MUW68_03255) 715502..716566 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW68_RS03260 (MUW68_03260) 716670..717617 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T241140 WP_003403218.1 NZ_CP095023:712306-712707 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T241140 NZ_LT907988:c914105-913806 [Orrella dioscoreae]
TTGATCCGCGTTTACACCACCCCCACATTTGATCGCTGGTTCGCACAGATCGACGACACGCTGACAGCCAAACGCATCCA
AGTCCGGATTCGCCGCCTGCAGCTCGGCAACCACGGAGACTGGGCGCCAATCGGTGAAGGTGTCGCGGAACTGCGGATCC
ATCATGGCCCCGGATACCGCGTGGTTTTCATGCCGCGAACCACGGACATCATCGTGCTGCTGGCAGGGGGCGACAAATCC
ACCCAGCCGCGGGACATCCGCGCCGCCCTGTCGCTGGCGCGCCAATTAAGGGAAACATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT241140 WP_003403213.1 NZ_CP095023:712082-712309 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT241140 NZ_LT907988:c913803-913507 [Orrella dioscoreae]
ATGACAAGGCCGACACTGCGGGAATGGGACAGCGCGGATCATCTCGGCACGGAGAAGGACCGCGTGCTGTATCTGCAGGC
CTGCATGGAAGAGGCAGGCGACGATGCCACCTTCATTGCCAAGGCCCTGGGCGACATTGCCCGCGCCAAAGGGATGACGC
AATTGGCACGAGACACAGGCCTGGGCCGGGAAAGCCTCTACAAGGCGCTGTCAGGCGAGGGAAATCCGAGTTTTGCCACC
ATATTGAAAGTGACCCGGGCGCTGGGCATCAGGCTGCAACCGCAACTGCAGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References