Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 696154..696800 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag MUW68_RS03115 Protein ID WP_003403122.1
Coordinates 696154..696546 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag MUW68_RS03120 Protein ID WP_003403125.1
Coordinates 696543..696800 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03100 (MUW68_03100) 691816..693342 + 1527 WP_003403112.1 virulence factor Mce family protein -
MUW68_RS03105 (MUW68_03105) 693405..694547 + 1143 WP_003911253.1 virulence factor Mce family protein -
MUW68_RS03110 (MUW68_03110) 694552..696102 + 1551 WP_003905349.1 MCE family protein -
MUW68_RS03115 (MUW68_03115) 696154..696546 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
MUW68_RS03120 (MUW68_03120) 696543..696800 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
MUW68_RS03125 (MUW68_03125) 696983..698218 - 1236 WP_003403128.1 ATP-binding protein -
MUW68_RS03130 (MUW68_03130) 698469..698882 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
MUW68_RS03135 (MUW68_03135) 698879..699115 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
MUW68_RS03140 (MUW68_03140) 699219..699725 - 507 WP_003900973.1 two component system sensor kinase HK1 -
MUW68_RS03145 (MUW68_03145) 699839..700369 - 531 WP_003917320.1 two component system sensor kinase HK2 -
MUW68_RS03150 (MUW68_03150) 700353..701033 - 681 WP_244733088.1 two-component system response regulator TcrA -
MUW68_RS03155 (MUW68_03155) 701156..701467 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T241137 WP_003403122.1 NZ_CP095023:c696546-696154 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T241137 NZ_LT907988:c259068-258790 [Orrella dioscoreae]
ATGATCTTGTCATTCCAGCACCGAGGCCTGAGACGATTCTTCGACACAGGTAGCGTGGCGGGCATCCAACCCCATCATGC
CGACAAGCTGCGGGAACTACTGACCGCGCTGAATGCCGCTAGTGCCCCTGCCGACTTGGCCCGCCCAAGCTGGCGTTATC
ACATGCTGACCGGCAAGCAAAAGGGCTTTGCGTCACTGACGGTCAACGGCAATTGGCGCCTCATCTTCCGCTGGCATGGA
CAAGACGTAGAGCTACTGGATTATCTGGACTATCACTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT241137 WP_003403125.1 NZ_CP095023:c696800-696543 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT241137 NZ_LT907988:c258780-258502 [Orrella dioscoreae]
ATGCACATGCACAATCCCGCCCATCCGGGCGAAATCCTCGCAGGCTGGCTGGCCGACCTGGGCACCAGCATCACCGCCTT
TGCTGCGCATATCGGCCTGTCCCGTGTGTTGGTCTCCAGGATCTTGCACGCCAAGGCGGGTATTACCGCCGACACGGATC
TGCGTCTATCCGATGCGCTGGGCACCACACCCGGCTATTGGCTGCGGATACAGGGTCAATACGACCTGTGGCAAGCAAGC
CAGAATGACAGGCCGGTGATCGAGCGACTTGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References