Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 679024..679643 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag MUW68_RS03050 Protein ID WP_003403047.1
Coordinates 679236..679643 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag MUW68_RS03045 Protein ID WP_003403039.1
Coordinates 679024..679239 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03035 (MUW68_03035) 677552..678310 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
MUW68_RS03040 (MUW68_03040) 678439..678930 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
MUW68_RS03045 (MUW68_03045) 679024..679239 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
MUW68_RS03050 (MUW68_03050) 679236..679643 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
MUW68_RS03055 (MUW68_03055) 679703..680389 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
MUW68_RS03060 (MUW68_03060) 680543..683176 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T241136 WP_003403047.1 NZ_CP095023:679236-679643 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T241136 NZ_LT907978:2190258-2190446 [Anaerobutyricum hallii]
ATGCCAATGAAACCACAAGAAATGATAAGATTATTAAAAAAGAATGGTTTCATAAAAATAAGTCAAAATGGTTCCCATGT
GAAAATGAAGAATTTTAAAACTGGCAAGCAAACAACAGTTCCTCTTCATAGCAAAGATTTAAAAAAAGGACTAGAAGATG
CTATCCTAAAACAAGCGGGCTTAAAATAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT241136 WP_003403039.1 NZ_CP095023:679024-679239 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT241136 NZ_LT907978:2190492-2190881 [Anaerobutyricum hallii]
ATGAAAAAATTATTTTATCCTGCTGTATTTCATATTGCAGAAGAAGGCGGTTATTGGGTGACTTTTCCTGACTTTCCCGA
ATGTCTAACTCAGGGAGAAAATATGCAAGAAGCCTATGATATGGCTATAGATGCTTTAGGACTTATCTTAACTGATGACA
TTAACGACCGTAAAGAACTTCCAGAACCGTCTAACATCACACATGTTGATGATGGAGTTGTCGTAATCATCCCATATGAT
TATTTGGAATATAATCGAAAGTATCATAATAAATCTATCAAAAAAACTTTAACAATCCCTGAATGGTTGAATAACGAAGC
ATTGCGATTGAATTTAAACTTTTCACAGATTTTGCAGGATGCTCTTTTAAACAAAATTCAATCTCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References