Detailed information of TA system TA241135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 641551..642227
• Replicon: chromosome
• Accession: NZ_CP095023
• Organism: Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TPQ9
• Locus tag: MUW68_RS02880
• Protein ID: WP_003898500.1
• Coordinates: 641551..641964 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TPR0
• Locus tag: MUW68_RS02885
• Protein ID: WP_003402915.1
• Coordinates: 641961..642227 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW68_RS02850 (MUW68_02850)	636896..637198	-	303	WP_003402896.1	DUF3349 domain-containing protein	-
MUW68_RS02855 (MUW68_02855)	637258..637536	-	279	WP_003402901.1	hypothetical protein	-
MUW68_RS02860 (MUW68_02860)	637533..638786	-	1254	WP_003402904.1	inorganic phosphate transporter	-
MUW68_RS02865 (MUW68_02865)	638906..639292	-	387	WP_003402907.1	VOC family protein	-
MUW68_RS02870 (MUW68_02870)	639355..640239	-	885	WP_003402909.1	SDR family oxidoreductase	-
MUW68_RS02875 (MUW68_02875)	640335..641237	-	903	WP_003915439.1	1,4-dihydroxy-2-naphthoyl-CoA synthase	-
MUW68_RS02880 (MUW68_02880)	641551..641964	-	414	WP_003898500.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW68_RS02885 (MUW68_02885)	641961..642227	-	267	WP_003402915.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
MUW68_RS02890 (MUW68_02890)	642419..644134	-	1716	WP_003402917.1	fatty-acid--CoA ligase FadD8	-
MUW68_RS02895 (MUW68_02895)	644212..645816	+	1605	WP_003402920.1	amidohydrolase	-
MUW68_RS02900 (MUW68_02900)	645813..646793	+	981	WP_003402923.1	o-succinylbenzoate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (13-129)

Antitoxin

• Post-segregation antitoxin CcdA (19-61)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14667.78 Da
• Isoelectric Point: 7.3603

>T241135 WP_003898500.1 NZ_CP095023:c641964-641551 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Nucleotide

• Length: 414 bp

>T241135 NZ_LT907978:851680-852297 [Anaerobutyricum hallii]
TTGGTCGATGATATTTTGAGGAAAGATGGTTTATCTTTGAAAAAATTAGAAATACTTTCTTACCGTTCTAATCTTGGCAT
TAATCTAAAGAAAAATTTGCATTATTTTATCAAAGAAGAATTATTTAAAGAATTGAAAGCGGTTAATCAATGGTATGATT
TATGTACAGAATTGGAAAGTGTTGCAATAGATTATCGTATAAAAAGTATACAATCAGCAAAATTAAAATATGCACGTTAT
TATCCTGACCATCAAACAAGGAAAGTATTTGACGACCTTTTGGGATTTCGAGCATTGTGTGATAATTATGAGGATATACA
TTCTCTTAGTAAAGAAGAACACATTCGCATTGCAAATATGAGTTGTGGGAAAGCTCATGATGATGGGTATAGAGGAGTTC
ATGTATATTATCAATTAAGCAATTATCATTATCCGATTGAGATACAATATAATACTTATTATGACCGCCAGCTAAATAAT
TGGCTTCATAAGTATATATATAAACAGAAATATGATAATGAAATTGGTTGTATTTTGCGAAGACTTTATGAAAATGGAAG
CATTAAAACAGAAAGTGAATTTAAAAAGGAGTTAGATTATGTGTTATCTAGTTGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9543.79 Da
• Isoelectric Point: 4.5994

>AT241135 WP_003402915.1 NZ_CP095023:c642227-641961 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Nucleotide

• Length: 267 bp

>AT241135 NZ_LT907978:852278-852502 [Anaerobutyricum hallii]
ATGTGTTATCTAGTTGCTAAAAAGTTTGGTAGTGTAGGATGTTCTGCTTTACAAACTACTCATGGACAACATTTAGTGGA
ATTGAAAAAAAGAATAATTGATAAAGTAGGGACAGATAAGATACAGTTGGTTACCATTAGCCGTCCATCTGCATATGGAG
AATATGAGCCGTATCATTTTTGTGACACAGAAGATGAATTTGAGAGAACAGTAGCAAAGATGTAA

Structures

Toxin

• AlphaFold DB: G0TPQ9

Antitoxin

• AlphaFold DB: G0TPR0