Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445475..446486 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MUW68_RS01920 Protein ID WP_003401859.1
Coordinates 445475..446068 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MUW68_RS01925 Protein ID WP_003401860.1
Coordinates 446097..446486 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS01900 (MUW68_01900) 441124..442506 + 1383 WP_003898415.1 magnesium transporter -
MUW68_RS01905 (MUW68_01905) 442518..443552 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MUW68_RS01910 (MUW68_01910) 443648..444331 + 684 WP_003401857.1 VTT domain-containing protein -
MUW68_RS01915 (MUW68_01915) 444320..445450 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MUW68_RS01920 (MUW68_01920) 445475..446068 - 594 WP_003401859.1 zeta toxin family protein Toxin
MUW68_RS01925 (MUW68_01925) 446097..446486 - 390 WP_003401860.1 hypothetical protein Antitoxin
MUW68_RS01930 (MUW68_01930) 446567..447778 - 1212 WP_003401861.1 VWA domain-containing protein -
MUW68_RS01935 (MUW68_01935) 447784..448386 - 603 WP_003898417.1 SRPBCC family protein -
MUW68_RS01940 (MUW68_01940) 448400..449296 - 897 WP_003898418.1 MoxR family ATPase -
MUW68_RS01945 (MUW68_01945) 449293..449886 - 594 WP_003401864.1 NTP transferase domain-containing protein -
MUW68_RS01950 (MUW68_01950) 449883..450638 - 756 WP_031665977.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T241134 WP_003401859.1 NZ_CP095023:c446068-445475 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T241134 NZ_LT906615:c433311-433033 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT241134 WP_003401860.1 NZ_CP095023:c446486-446097 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT241134 NZ_LT906615:c433592-433308 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References