Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 365178..365821 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MUW68_RS01585 Protein ID WP_003401566.1
Coordinates 365396..365821 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MUW68_RS01580 Protein ID WP_003401563.1
Coordinates 365178..365399 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS01555 (MUW68_01555) 360297..361100 - 804 WP_003401540.1 Stf0 family sulphotransferase -
MUW68_RS01560 (MUW68_01560) 361110..362507 - 1398 WP_003401544.1 sulfatase -
MUW68_RS01565 (MUW68_01565) 362686..364461 + 1776 WP_010886074.1 PE family protein -
MUW68_RS01570 (MUW68_01570) 364604..364831 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MUW68_RS01575 (MUW68_01575) 364828..365130 + 303 WP_003401560.1 toxin-antitoxin system toxin -
MUW68_RS01580 (MUW68_01580) 365178..365399 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MUW68_RS01585 (MUW68_01585) 365396..365821 + 426 WP_003401566.1 PIN domain nuclease Toxin
MUW68_RS01590 (MUW68_01590) 365957..366589 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
MUW68_RS01595 (MUW68_01595) 366586..367494 + 909 WP_003900117.1 protochlorophyllide reductase -
MUW68_RS01600 (MUW68_01600) 367502..368092 - 591 WP_229298012.1 hypothetical protein -
MUW68_RS01605 (MUW68_01605) 368085..368135 - 51 Protein_318 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T241133 WP_003401566.1 NZ_CP095023:365396-365821 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T241133 NZ_LT906615:431040-431309 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT241133 WP_003401563.1 NZ_CP095023:365178-365399 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT241133 NZ_LT906615:431303-431824 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References