Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Rv0299-vapB/- |
Location | 364828..365399 | Replicon | chromosome |
Accession | NZ_CP095023 | ||
Organism | Mycobacterium tuberculosis strain SGF0702019 |
Toxin (Protein)
Gene name | Rv0299 | Uniprot ID | - |
Locus tag | MUW68_RS01575 | Protein ID | WP_003401560.1 |
Coordinates | 364828..365130 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | O07227 |
Locus tag | MUW68_RS01580 | Protein ID | WP_003401563.1 |
Coordinates | 365178..365399 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MUW68_RS01555 (MUW68_01555) | 360297..361100 | - | 804 | WP_003401540.1 | Stf0 family sulphotransferase | - |
MUW68_RS01560 (MUW68_01560) | 361110..362507 | - | 1398 | WP_003401544.1 | sulfatase | - |
MUW68_RS01565 (MUW68_01565) | 362686..364461 | + | 1776 | WP_010886074.1 | PE family protein | - |
MUW68_RS01570 (MUW68_01570) | 364604..364831 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | - |
MUW68_RS01575 (MUW68_01575) | 364828..365130 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | Toxin |
MUW68_RS01580 (MUW68_01580) | 365178..365399 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | Antitoxin |
MUW68_RS01585 (MUW68_01585) | 365396..365821 | + | 426 | WP_003401566.1 | PIN domain nuclease | - |
MUW68_RS01590 (MUW68_01590) | 365957..366589 | + | 633 | WP_003401571.1 | TetR/AcrR family transcriptional regulator | - |
MUW68_RS01595 (MUW68_01595) | 366586..367494 | + | 909 | WP_003900117.1 | protochlorophyllide reductase | - |
MUW68_RS01600 (MUW68_01600) | 367502..368092 | - | 591 | WP_229298012.1 | hypothetical protein | - |
MUW68_RS01605 (MUW68_01605) | 368085..368135 | - | 51 | Protein_318 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 10442.16 Da Isoelectric Point: 4.9609
>T241132 WP_003401560.1 NZ_CP095023:364828-365130 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
Download Length: 303 bp
>T241132 NZ_LT906615:431040-431309 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8088.31 Da Isoelectric Point: 10.7177
>AT241132 WP_003401563.1 NZ_CP095023:365178-365399 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
Download Length: 222 bp
>AT241132 NZ_LT906615:430905-431009 [Vibrio cholerae O1 biovar El Tor str. N16961]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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