Detailed information of TA system TA241131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 364604..365130
• Replicon: chromosome
• Accession: NZ_CP095023
• Organism: Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: MUW68_RS01575
• Protein ID: WP_003401560.1
• Coordinates: 364828..365130 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: MUW68_RS01570
• Protein ID: WP_003401555.1
• Coordinates: 364604..364831 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW68_RS01555 (MUW68_01555)	360297..361100	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
MUW68_RS01560 (MUW68_01560)	361110..362507	-	1398	WP_003401544.1	sulfatase	-
MUW68_RS01565 (MUW68_01565)	362686..364461	+	1776	WP_010886074.1	PE family protein	-
MUW68_RS01570 (MUW68_01570)	364604..364831	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
MUW68_RS01575 (MUW68_01575)	364828..365130	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
MUW68_RS01580 (MUW68_01580)	365178..365399	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
MUW68_RS01585 (MUW68_01585)	365396..365821	+	426	WP_003401566.1	PIN domain nuclease	-
MUW68_RS01590 (MUW68_01590)	365957..366589	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
MUW68_RS01595 (MUW68_01595)	366586..367494	+	909	WP_003900117.1	protochlorophyllide reductase	-
MUW68_RS01600 (MUW68_01600)	367502..368092	-	591	WP_229298012.1	hypothetical protein	-
MUW68_RS01605 (MUW68_01605)	368085..368135	-	51	Protein_318	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T241131 WP_003401560.1 NZ_CP095023:364828-365130 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T241131 NZ_LT906615:425870-426172 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT241131 WP_003401555.1 NZ_CP095023:364604-364831 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT241131 NZ_LT906615:425625-425882 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1