Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3774995..3775524 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MUW67_RS17785 Protein ID WP_003417760.1
Coordinates 3775267..3775524 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MUW67_RS17780 Protein ID WP_003417757.1
Coordinates 3774995..3775270 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS17745 (MUW67_17745) 3771568..3772257 - 690 WP_003917774.1 BBE domain-containing protein -
MUW67_RS17750 (MUW67_17750) 3772444..3772815 - 372 WP_003417739.1 FAD-binding protein -
MUW67_RS17755 (MUW67_17755) 3772713..3772931 - 219 WP_157132559.1 hypothetical protein -
MUW67_RS17760 (MUW67_17760) 3772958..3773218 - 261 WP_003417741.1 hypothetical protein -
MUW67_RS17765 (MUW67_17765) 3773333..3773722 + 390 WP_003417745.1 DUF732 domain-containing protein -
MUW67_RS17770 (MUW67_17770) 3773736..3774029 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MUW67_RS17775 (MUW67_17775) 3774026..3774871 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MUW67_RS17780 (MUW67_17780) 3774995..3775270 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MUW67_RS17785 (MUW67_17785) 3775267..3775524 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MUW67_RS17790 (MUW67_17790) 3775566..3776756 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MUW67_RS17795 (MUW67_17795) 3776873..3777241 + 369 WP_003417765.1 FHA domain-containing protein -
MUW67_RS17800 (MUW67_17800) 3777238..3777789 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MUW67_RS17805 (MUW67_17805) 3777796..3778377 - 582 WP_003417769.1 ATP/GTP-binding protein -
MUW67_RS17810 (MUW67_17810) 3778358..3778726 - 369 WP_003417772.1 DUF742 domain-containing protein -
MUW67_RS17815 (MUW67_17815) 3778704..3779096 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T241127 WP_003417760.1 NZ_CP095022:3775267-3775524 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T241127 NZ_LT906615:418782-419183 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT241127 WP_003417757.1 NZ_CP095022:3774995-3775270 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT241127 NZ_LT906615:418090-418782 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References