Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3703193..3703867 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MUW67_RS17555 Protein ID WP_003417282.1
Coordinates 3703193..3703621 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MUW67_RS17560 Protein ID WP_003417286.1
Coordinates 3703625..3703867 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS17530 (MUW67_17530) 3699015..3699416 - 402 WP_003417264.1 cytidine deaminase -
MUW67_RS17535 (MUW67_17535) 3699653..3699991 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
MUW67_RS17540 (MUW67_17540) 3699988..3700422 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MUW67_RS17545 (MUW67_17545) 3700551..3702323 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MUW67_RS17550 (MUW67_17550) 3702323..3703114 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MUW67_RS17555 (MUW67_17555) 3703193..3703621 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW67_RS17560 (MUW67_17560) 3703625..3703867 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
MUW67_RS17565 (MUW67_17565) 3703989..3704603 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MUW67_RS17570 (MUW67_17570) 3704600..3705265 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MUW67_RS17575 (MUW67_17575) 3705266..3705799 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MUW67_RS17580 (MUW67_17580) 3705796..3706170 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
MUW67_RS17585 (MUW67_17585) 3706267..3707403 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T241126 WP_003417282.1 NZ_CP095022:c3703621-3703193 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T241126 NZ_LT906615:414947-415279 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT241126 WP_003417286.1 NZ_CP095022:c3703867-3703625 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT241126 NZ_LT906615:415266-415580 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References