Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3167292..3167840 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MUW67_RS15130 Protein ID WP_003414602.1
Coordinates 3167577..3167840 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag MUW67_RS15125 Protein ID WP_003414599.1
Coordinates 3167292..3167573 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS15100 (MUW67_15100) 3162916..3163773 - 858 WP_003899513.1 type I methionyl aminopeptidase -
MUW67_RS15105 (MUW67_15105) 3163815..3164399 - 585 WP_003414585.1 DUF1707 domain-containing protein -
MUW67_RS15110 (MUW67_15110) 3164502..3164750 + 249 WP_003913411.1 antitoxin VapB23 -
MUW67_RS15115 (MUW67_15115) 3164747..3165127 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
MUW67_RS15120 (MUW67_15120) 3165209..3167020 - 1812 WP_003414596.1 penicillin-binding protein -
MUW67_RS15125 (MUW67_15125) 3167292..3167573 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MUW67_RS15130 (MUW67_15130) 3167577..3167840 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUW67_RS15135 (MUW67_15135) 3168213..3169067 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MUW67_RS15140 (MUW67_15140) 3169123..3170286 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MUW67_RS15145 (MUW67_15145) 3170303..3171517 - 1215 WP_003414610.1 zinc metalloprotease Rip -
MUW67_RS15150 (MUW67_15150) 3171525..3172766 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T241123 WP_003414602.1 NZ_CP095022:3167577-3167840 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T241123 NZ_LT906615:c365665-365348 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT241123 WP_003414599.1 NZ_CP095022:3167292-3167573 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT241123 NZ_LT906615:c365926-365684 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References