Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2865221..2865930 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag MUW67_RS13470 Protein ID WP_003413164.1
Coordinates 2865221..2865634 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag MUW67_RS13475 Protein ID WP_003413167.1
Coordinates 2865673..2865930 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T241113 WP_003413164.1 NZ_CP095022:2865221-2865634 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T241113 NZ_LT906483:3385400-3385738 [Mycolicibacterium thermoresistibile]
ATGTGGGAGGTCATCCTGGTCGAGGAGGTGGAACAGTGGTTCTTCAGCCTGGACCCCGATGTGATTGACGTGGTTACCGG
TGCCATCGACCGGTTGGAGGAGAGCGGACCAGCGTTGGGACGCCCGACCGCCGACCGGGTGAAGGGCTCCAAGTACCACC
ACATGAAGGAGCTGCGCCCCGCAGGCACCAGCATCCGCATCCTGTACATCTTCGACCCGACGCGGCGAGCAGTGCTGCTG
GTGGCGGGCGACAAGGCAGGACAGTGGAAGAAGTGGTATCAGGACAACATCCCCGTGGCGGAACAGCGCTACGAGAGATG
GTTTGAGAGAGGTGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT241113 WP_003413167.1 NZ_CP095022:2865673-2865930 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT241113 NZ_LT906483:3385740-3386066 [Mycolicibacterium thermoresistibile]
ATGGCACGCAGTTGGCGGGATGTCCGGGCTGAGGCGGTCGCCTCAGGTCGTGTCGATCCGGCGCGGGCTGACGCCGCGCG
CAGGCGGATGAAGGTGATGGAGCACGCTCACACGCTGGCTGAAGTGCGCAAGACCCTCGGCATGTTGCGCCAGGAGGACA
TCGCTCAGCGCATGGGAGTGTCCCAGGCTCGCGTGTCGAAGCTGGAGCGCGGCGACCTGGCGCACACCGAGCTGGGAACG
CTGCTGTCCTACATTCAGGCGATGGGCGGCGAACTGAAGATCGAGGCGCGGATCGGTGACAACAGCATCGACCTGATCCC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References