Detailed information of TA system TA241112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2851335..2851975
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: MUW67_RS13385
• Protein ID: WP_003412970.1
• Coordinates: 2851335..2851754 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: MUW67_RS13390
• Protein ID: WP_003412975.1
• Coordinates: 2851751..2851975 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS13355 (MUW67_13355)	2846925..2847647	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
MUW67_RS13360 (MUW67_13360)	2848164..2848386	+	223	Protein_2636	type II toxin-antitoxin system VapB family antitoxin	-
MUW67_RS13365 (MUW67_13365)	2848383..2848784	+	402	WP_003412963.1	PIN domain-containing protein	-
MUW67_RS13370 (MUW67_13370)	2848819..2849739	-	921	WP_003412965.1	restriction endonuclease	-
MUW67_RS13375 (MUW67_13375)	2850080..2850325	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
MUW67_RS13380 (MUW67_13380)	2850384..2851334	+	951	WP_003911916.1	ERCC4 domain-containing protein	-
MUW67_RS13385 (MUW67_13385)	2851335..2851754	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW67_RS13390 (MUW67_13390)	2851751..2851975	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
MUW67_RS13395 (MUW67_13395)	2852006..2854849	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
MUW67_RS13400 (MUW67_13400)	2854921..2855322	-	402	WP_003412981.1	hypothetical protein	-
MUW67_RS13405 (MUW67_13405)	2855322..2855792	-	471	WP_003899364.1	transcription antitermination factor NusB	-
MUW67_RS13410 (MUW67_13410)	2855795..2856358	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T241112 WP_003412970.1 NZ_CP095022:c2851754-2851335 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T241112 NZ_LT906480:301796-302098 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT241112 WP_003412975.1 NZ_CP095022:c2851975-2851751 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT241112 NZ_LT906480:301450-301755 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09