Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2805157..2805809 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag MUW67_RS13190 Protein ID WP_003905869.1
Coordinates 2805384..2805809 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MUW67_RS13185 Protein ID WP_003412749.1
Coordinates 2805157..2805378 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS13170 (MUW67_13170) 2803397..2803603 - 207 WP_003899347.1 hypothetical protein -
MUW67_RS13175 (MUW67_13175) 2803739..2804362 + 624 WP_003900858.1 TIGR00725 family protein -
MUW67_RS13180 (MUW67_13180) 2804352..2805104 + 753 WP_003901416.1 hypothetical protein -
MUW67_RS13185 (MUW67_13185) 2805157..2805378 + 222 WP_003412749.1 antitoxin Antitoxin
MUW67_RS13190 (MUW67_13190) 2805384..2805809 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW67_RS13195 (MUW67_13195) 2805832..2807013 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
MUW67_RS13200 (MUW67_13200) 2807010..2808056 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MUW67_RS13205 (MUW67_13205) 2808067..2809170 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MUW67_RS13210 (MUW67_13210) 2809429..2810250 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MUW67_RS13215 (MUW67_13215) 2810247..2810804 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T241111 WP_003905869.1 NZ_CP095022:2805384-2805809 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T241111 NZ_LT906480:301450-301755 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT241111 WP_003412749.1 NZ_CP095022:2805157-2805378 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT241111 NZ_LT906480:301796-302098 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References