Detailed information of TA system TA241109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2363072..2363767
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUW67_RS11070
• Protein ID: WP_003905754.1
• Coordinates: 2363072..2363506 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: MUW67_RS11075
• Protein ID: WP_003410814.1
• Coordinates: 2363513..2363767 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS11060 (MUW67_11060)	2359226..2362267	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
MUW67_RS11065 (MUW67_11065)	2362260..2363093	+	834	WP_003899172.1	SWIM zinc finger family protein	-
MUW67_RS11070 (MUW67_11070)	2363072..2363506	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW67_RS11075 (MUW67_11075)	2363513..2363767	-	255	WP_003410814.1	antitoxin	Antitoxin
MUW67_RS11080 (MUW67_11080)	2363783..2364040	-	258	WP_003410816.1	hypothetical protein	-
MUW67_RS11085 (MUW67_11085)	2364574..2365835	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
MUW67_RS11095 (MUW67_11095)	2367704..2368000	+	297	WP_003410820.1	PE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T241109 WP_003905754.1 NZ_CP095022:c2363506-2363072 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T241109 NZ_LT906479:4881198-4881677 [Serratia ficaria]
ATGATTATTCTCGACACCAACGTCATGTCAGAAACGCTGCGCCCCAGCCCGCACTACAACGTCATAAACTGGTTAAACGA
AAAGGACAATGACGAGCTCTACCTGAGCGCCATTGTCATTGCCGAGCTGTTCAACGGCGCCGCCTGCATGCCTGACGGCA
AGCGTCAGCGGGATCTGAAGCTCAAATTGGCGGACGCCATCCAGCTGAAGTTCGAAGGGCAAACTCTGCCGTTTGACGGG
CTGTGCGCGATGCAATACGCGGAGTTGACGGCAAGAAACCGGCTGCAGGGCAAGCTGATGAGCGTACCGGATGCCCAAAT
CGCCGCCACCTGCCTGCACTACGGCGCCGCCCTGGCCACCCGCAACAGCAAAAACTTTCTCCACTGCGGCATCGAGTTAA
TCGATCCCTGGCAGGCGCCGGCCGGCCGTCGGCTGCATGAGGATGCGGCGGAATACTACGTGATGAGCAGGAAGTCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT241109 WP_003410814.1 NZ_CP095022:c2363767-2363513 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT241109 NZ_LT906479:4880938-4881201 [Serratia ficaria]
ATGGCTACTATAACCGTCAGGAATCTGGACGATGAGATAAAAGAGCTGCTGCGCATTTCGGCAGCGAAAAATGGCCATTC
GATGGAAGAGGAAGCGCGCACGATCCTGAAACAGGCGCTGGTGAAAAAGCCGCCGCGCTACGGGTTGGGTACCTGGATGC
ATCAGCACTTCGCCGAATTTGGCGGCGTCGAGCTGGACATTCCGCCGCGAGACGCCGTGCCGCCTCGCATAGTCAGCTTT
GATGATGAAGATGACAACGCATGA

Structures

Antitoxin

• AlphaFold DB: G0TMN0