Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2319730..2320366 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag MUW67_RS10875 Protein ID WP_003410654.1
Coordinates 2319956..2320366 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MUW67_RS10870 Protein ID WP_003410651.1
Coordinates 2319730..2319963 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS10855 (MUW67_10855) 2315178..2315579 + 402 WP_009937711.1 metal ABC transporter permease -
MUW67_RS10860 (MUW67_10860) 2315580..2315984 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
MUW67_RS10865 (MUW67_10865) 2316068..2319652 - 3585 WP_244753758.1 cobaltochelatase subunit CobN -
MUW67_RS10870 (MUW67_10870) 2319730..2319963 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
MUW67_RS10875 (MUW67_10875) 2319956..2320366 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
MUW67_RS10880 (MUW67_10880) 2320350..2321441 + 1092 WP_003900454.1 precorrin-3B synthase -
MUW67_RS10885 (MUW67_10885) 2321451..2322077 + 627 WP_003410658.1 precorrin-8X methylmutase -
MUW67_RS10890 (MUW67_10890) 2322074..2323600 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
MUW67_RS10895 (MUW67_10895) 2323546..2324769 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T241108 WP_003410654.1 NZ_CP095022:2319956-2320366 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T241108 NZ_LT906479:4564599-4564889 [Serratia ficaria]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCATGCGCAGCCGTCTGATTCCCGGTATGCT
CGAACGGCAGTTGGCCAGAAAGCTCGATATGTTGGCGGCCGCGCAGCAAGAGCGCGATTTGCATCACCCCACGGGCAACT
ATTACAAGCGGCTGTCGGGGCCGTTTCAGGGATGGTCAAGTCTGCGCGTTAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAGAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT241108 WP_003410651.1 NZ_CP095022:2319730-2319963 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT241108 NZ_LT906479:4564904-4565227 [Serratia ficaria]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGGGAAGTGCTGCAGGAAGAGTATTTAACGCCGTTGGGCATCGG
CCAGGAAGAACTGGCGAAGGTACTGGGCGTTACCCGCGCCACCGTTAACCGCCTGTGCAATGGGCATCGGCGCATGAGCG
TTGCCGAGGCCAACCTGTTTGCCGATCTGTTCGAAACGACCGCCGACTTTTGGCTGAACCTGCAGGCGGCGCACGATCGC
TGGGAGGCCAGACAGGCCGATGCGCAACGTGTGCGGCTTCGGCCAATCAAAGAAATACTGGGACGCAATATCACTCATGC
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References