Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2225490..2226076 | Replicon | chromosome |
| Accession | NZ_CP095022 | ||
| Organism | Mycobacterium tuberculosis strain SGF0472017 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | MUW67_RS10460 | Protein ID | WP_003410010.1 |
| Coordinates | 2225490..2225834 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | MUW67_RS10465 | Protein ID | WP_003410014.1 |
| Coordinates | 2225828..2226076 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW67_RS10425 (MUW67_10425) | 2221196..2221795 | + | 600 | WP_003910883.1 | L-lysine exporter | - |
| MUW67_RS10430 (MUW67_10430) | 2222211..2222639 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| MUW67_RS10435 (MUW67_10435) | 2222865..2223404 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| MUW67_RS10440 (MUW67_10440) | 2223924..2224484 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| MUW67_RS10445 (MUW67_10445) | 2224481..2224822 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| MUW67_RS10450 (MUW67_10450) | 2224908..2225165 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| MUW67_RS10455 (MUW67_10455) | 2225066..2225401 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| MUW67_RS10460 (MUW67_10460) | 2225490..2225834 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| MUW67_RS10465 (MUW67_10465) | 2225828..2226076 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| MUW67_RS10470 (MUW67_10470) | 2226176..2228491 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| MUW67_RS10475 (MUW67_10475) | 2228488..2228760 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| MUW67_RS10480 (MUW67_10480) | 2228813..2229169 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| MUW67_RS10485 (MUW67_10485) | 2229326..2230093 | + | 768 | WP_003410019.1 | hemerythrin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T241105 WP_003410010.1 NZ_CP095022:c2225834-2225490 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T241105 NZ_LT906479:4199244-4199588 [Serratia ficaria]
ATGTGGCAGGTCGCGACCGTCGAAATATTCGACGCCTGGTTTTTATCGCTGAGTGGCGACCAGCAAAAAAGCATCCTGGC
GGGGATTTTCAAACTGCAGGAATTCGGCCCCCAGCTGGCAAGGCCATATGCCGACACGCTGCATTTTCCCGGTTCAATAC
ACCGCATGAAAGAGCTGCGCATTCAACACCGCGGCCACCCGTTTCGGTTTTTTTTCGCCTTCGATCCACAACGGCAGGCG
GTGCTGTTGTGCGGTGGCGACAAAACCGGCGACAAGCGTTTCTGCCAGCGCCTGTTGCCCATCGCCGCCAGGGAGTTCTC
ACATTATCTGGCAACCCAGAGGTAA
ATGTGGCAGGTCGCGACCGTCGAAATATTCGACGCCTGGTTTTTATCGCTGAGTGGCGACCAGCAAAAAAGCATCCTGGC
GGGGATTTTCAAACTGCAGGAATTCGGCCCCCAGCTGGCAAGGCCATATGCCGACACGCTGCATTTTCCCGGTTCAATAC
ACCGCATGAAAGAGCTGCGCATTCAACACCGCGGCCACCCGTTTCGGTTTTTTTTCGCCTTCGATCCACAACGGCAGGCG
GTGCTGTTGTGCGGTGGCGACAAAACCGGCGACAAGCGTTTCTGCCAGCGCCTGTTGCCCATCGCCGCCAGGGAGTTCTC
ACATTATCTGGCAACCCAGAGGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT241105 WP_003410014.1 NZ_CP095022:c2226076-2225828 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT241105 NZ_LT906479:4199594-4199896 [Serratia ficaria]
ATGGCCAAACCTTTATCCCATCGGATCGATAAGCTCGATCCCGCCGTCGTTGCGGCGGCCAGGCAAAAAGCGGACCAAGA
AATTTTTGAACTGCGGCTGGCGATGCTGCGGGAAGAGTTGGCGGTTTCGCAGGTCGAGCTGGCGAAGCGGCTTGGCATCA
GCCAACCCTCAGTCGCCAACCTGGAAAAACGCGGCAGCGAGATAAAACTGTCTTCGCTTAAACGCTATATAGAAGCCATG
GGCGGTACGCTGTCGCTGGATGTCCGACTGCCCAACGGCCAGCACCGCCGCATGACGCTGTGA
ATGGCCAAACCTTTATCCCATCGGATCGATAAGCTCGATCCCGCCGTCGTTGCGGCGGCCAGGCAAAAAGCGGACCAAGA
AATTTTTGAACTGCGGCTGGCGATGCTGCGGGAAGAGTTGGCGGTTTCGCAGGTCGAGCTGGCGAAGCGGCTTGGCATCA
GCCAACCCTCAGTCGCCAACCTGGAAAAACGCGGCAGCGAGATAAAACTGTCTTCGCTTAAACGCTATATAGAAGCCATG
GGCGGTACGCTGTCGCTGGATGTCCGACTGCCCAACGGCCAGCACCGCCGCATGACGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|