Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2216598..2217286 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MUW67_RS10395 Protein ID WP_003409958.1
Coordinates 2216598..2217017 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MUW67_RS10400 Protein ID WP_003409968.1
Coordinates 2217026..2217286 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS10375 (MUW67_10375) 2212093..2212941 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
MUW67_RS10380 (MUW67_10380) 2212904..2214349 - 1446 WP_003899115.1 APC family permease -
MUW67_RS10385 (MUW67_10385) 2214528..2215214 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MUW67_RS10390 (MUW67_10390) 2215405..2216373 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MUW67_RS10395 (MUW67_10395) 2216598..2217017 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW67_RS10400 (MUW67_10400) 2217026..2217286 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW67_RS10405 (MUW67_10405) 2217429..2219105 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
MUW67_RS10410 (MUW67_10410) 2219093..2219746 - 654 WP_003409976.1 cutinase Cfp21 -
MUW67_RS10415 (MUW67_10415) 2219861..2220091 + 231 WP_003409980.1 DUF167 domain-containing protein -
MUW67_RS10420 (MUW67_10420) 2220176..2221087 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MUW67_RS10425 (MUW67_10425) 2221196..2221795 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T241103 WP_003409958.1 NZ_CP095022:c2217017-2216598 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T241103 NZ_LT906479:c3160877-3160479 [Serratia ficaria]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCTCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCGGGCAAAATGGTCATTTCGTCGGTCACCTATGGCGAATTGGTTCACGGAGTGGAGAAAAGCTCGCGTCCGG
CGGTTAACGCGAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCTTCGCACTAC
GGCAACATTCGGGCTGCGCTGGAGCGTCAGGGAACGCCTATTGGCGTAAACGATCTGCATATCGCTGGGCATGCGCGCAG
CGAAGGATTGATTCTGGTGACCAATAACCGACGCGAATTTGAGCGCGTTGATGGCTTACGGCTGGAAAATTGGCTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT241103 WP_003409968.1 NZ_CP095022:c2217286-2217026 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT241103 NZ_LT906479:c3161110-3160877 [Serratia ficaria]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTACAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGCG
CGGAAAATGAGGTGAGCGATGACTTCCTCAATGAACGCGCCGGGCAACACCAGCGCGAGCGGGAAGAGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References