Detailed information of TA system TA241102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2190370..2190914
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TLU9
• Locus tag: MUW67_RS10240
• Protein ID: WP_003409896.1
• Coordinates: 2190370..2190666 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P67299
• Locus tag: MUW67_RS10245
• Protein ID: WP_003409899.1
• Coordinates: 2190663..2190914 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS10185 (MUW67_10185)	2185403..2185753	-	351	WP_003409871.1	hypothetical protein	-
MUW67_RS10190 (MUW67_10190)	2185764..2186666	-	903	WP_003899097.1	hypothetical protein	-
MUW67_RS10195 (MUW67_10195)	2186687..2186878	-	192	WP_003409876.1	hypothetical protein	-
MUW67_RS10200 (MUW67_10200)	2186879..2187175	-	297	WP_003409877.1	hypothetical protein	-
MUW67_RS10205 (MUW67_10205)	2187415..2187630	+	216	WP_003409878.1	antitoxin	-
MUW67_RS10210 (MUW67_10210)	2187627..2187938	+	312	WP_003409881.1	type II toxin-antitoxin system VapC family toxin	-
MUW67_RS10215 (MUW67_10215)	2187912..2188433	-	522	WP_003904745.1	hypothetical protein	-
MUW67_RS10220 (MUW67_10220)	2188408..2188785	+	378	WP_010886136.1	type II toxin-antitoxin system toxin HigB	-
MUW67_RS10225 (MUW67_10225)	2188827..2189276	+	450	WP_003409886.1	type II toxin-antitoxin system antitoxin HigA	-
MUW67_RS10230 (MUW67_10230)	2189273..2189818	+	546	WP_003409891.1	SecB-like chaperone	-
MUW67_RS10235 (MUW67_10235)	2189707..2190321	-	615	WP_003901296.1	hypothetical protein	-
MUW67_RS10240 (MUW67_10240)	2190370..2190666	-	297	WP_003409896.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MUW67_RS10245 (MUW67_10245)	2190663..2190914	-	252	WP_003409899.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MUW67_RS10250 (MUW67_10250)	2190901..2191395	+	495	WP_003899099.1	hypothetical protein	-
MUW67_RS10255 (MUW67_10255)	2191555..2191962	-	408	WP_003409913.1	type II toxin-antitoxin system VapC family toxin	-
MUW67_RS10260 (MUW67_10260)	2191966..2192238	-	273	WP_003899100.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MUW67_RS10265 (MUW67_10265)	2192271..2193491	-	1221	WP_003409919.1	TetR family transcriptional regulator Mce3R	-
MUW67_RS10270 (MUW67_10270)	2194390..2195187	+	798	WP_003899101.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11268.64 Da
• Isoelectric Point: 6.8604

>T241102 WP_003409896.1 NZ_CP095022:c2190666-2190370 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Nucleotide

• Length: 297 bp

>T241102 NZ_LT906479:2100404-2100500 [Serratia ficaria]
AACAAGCCCTGCACTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9207.17 Da
• Isoelectric Point: 7.0150

>AT241102 WP_003409899.1 NZ_CP095022:c2190914-2190663 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Nucleotide

• Length: 252 bp

>AT241102 NZ_LT906479:c2100509-2100382 [Serratia ficaria]
TTAATACACAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAA
AGTTGGCATTTAGTGCAGGGCTTGTTCAGCCATGCACTTTAAGAGTAG

Structures

Toxin

• AlphaFold DB: G0TLU9

Antitoxin

• AlphaFold DB: A0A7U4BUZ2