Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1961926..1962386 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag MUW67_RS09170 Protein ID WP_003898996.1
Coordinates 1962138..1962386 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag MUW67_RS09165 Protein ID WP_003408528.1
Coordinates 1961926..1962138 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS09150 (MUW67_09150) 1958404..1959591 - 1188 WP_003898992.1 nitrate transporter NarK -
MUW67_RS09155 (MUW67_09155) 1959878..1960162 + 285 WP_003408522.1 DUF1876 domain-containing protein -
MUW67_RS09160 (MUW67_09160) 1960176..1961858 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
MUW67_RS09165 (MUW67_09165) 1961926..1962138 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW67_RS09170 (MUW67_09170) 1962138..1962386 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW67_RS09175 (MUW67_09175) 1962394..1963131 + 738 WP_003898997.1 hypothetical protein -
MUW67_RS09180 (MUW67_09180) 1963225..1964925 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
MUW67_RS09185 (MUW67_09185) 1965210..1965611 - 402 WP_003408538.1 hypothetical protein -
MUW67_RS09190 (MUW67_09190) 1965601..1966212 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T241099 WP_003898996.1 NZ_CP095022:1962138-1962386 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T241099 NZ_LT906479:65579-65854 [Serratia ficaria]
ATGGATTTAAAATGGACAAGTAAAGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTGCTTGCATCGGTTAATCATGCTGC
CGCAGCTAATACGGTACAGGCTTTGGTTGCAGCACCGAAAGTACTGCGTGATAACCCCCGTATTGGGGAGAAATTGGATG
AATTTATGCCGCATGAGGTGAGGCGTATACTCGTTGGTCGTTATGAAATGCGCTACCAACTTCAATCCTCAACAATTTAT
ATCCTGCGTATTTGGCATACACGTGAAGAGCGTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT241099 WP_003408528.1 NZ_CP095022:1961926-1962138 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT241099 NZ_LT906479:65319-65579 [Serratia ficaria]
ATGAATACTAAAGTCATCACCGCACATGTGCCGTTACCCTTGGTGGAAAAAGTCGATGAGATGGCTGCCAAGCTGGAGCG
CTCACGCGGATGGATCGTTAAGCAGGCGCTCACCGCATGGCTCGATCAGGAAGAAGAACGTCGTCGATTAACACTGGCGG
CATTGACCGATGTCGAACAGCAGAATGTTATCGATCATGAATCGGTTGAAGCCTGGGCCGCGAGCCTGAGCAGCGATAAG
CCTCTGCCGGTACCGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References