Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1768060..1768673 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag MUW67_RS08305 Protein ID WP_003407786.1
Coordinates 1768269..1768673 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag MUW67_RS08300 Protein ID WP_009935474.1
Coordinates 1768060..1768263 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS08270 (MUW67_08270) 1763465..1763845 + 381 WP_003407768.1 fumarate reductase subunit C -
MUW67_RS08275 (MUW67_08275) 1763842..1764219 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
MUW67_RS08280 (MUW67_08280) 1764287..1764895 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
MUW67_RS08285 (MUW67_08285) 1765079..1766227 + 1149 Protein_1632 MMPL family transporter -
MUW67_RS08290 (MUW67_08290) 1766237..1766683 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
MUW67_RS08295 (MUW67_08295) 1766718..1768007 + 1290 WP_003407781.1 threonine ammonia-lyase -
MUW67_RS08300 (MUW67_08300) 1768060..1768263 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW67_RS08305 (MUW67_08305) 1768269..1768673 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
MUW67_RS08310 (MUW67_08310) 1768690..1770432 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
MUW67_RS08315 (MUW67_08315) 1770425..1772722 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T241097 WP_003407786.1 NZ_CP095022:1768269-1768673 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T241097 NZ_LT906476:c3325425-3325129 [Legionella pneumophila]
ATGATTTATGAGCTTCATTTTCATCCTTTAGCTTTAAAAGAATGGAAAAAGCTGGGGAAAAACCTTCAAGAAGAATTTAA
GAAAGTGTTAAAACGCCGTTTAGAAAATCCACATGTGGCTTCGGCTAGCTTAAGAGGCTCTTTAAAAAATTGCTATAAAA
TAAAATTACGTCAATCTGGTTATCGTTTGGTGTATCAAGTTAATGATAATAAATTAATTGTAACCGTCATAGCAGTCGGG
AAAAGAAACAAAAATGTTGTCTATGATGATGCAGATAACCGACAAGAAGACAGTTAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT241097 WP_009935474.1 NZ_CP095022:1768060-1768263 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT241097 NZ_LT906476:c3325666-3325415 [Legionella pneumophila]
ATGCAAACTTTATTTGCTACACAAGTAGCGAGCATTAGTGAATTAAAAAAGAACCCCACTAAGCTCATTAATGATGCTCA
TGGAAAACCTGTTGCTATTCTTAACCACAATACAGCGGCAGCATATTTAATTCCTGTTGAAACATTTGAAAAACTAATGG
ATTTGATTGATGAGAATGAACTACATAAAATAGTAGAAGAGCGTTTGTCAGCACCTTTTACCTCAATAAAGGTAAATATT
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References