Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689562..1690178 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MUW67_RS07960 Protein ID WP_003407593.1
Coordinates 1689861..1690178 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MUW67_RS07955 Protein ID WP_003900349.1
Coordinates 1689562..1689864 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS07945 (MUW67_07945) 1685448..1687295 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
MUW67_RS07950 (MUW67_07950) 1687296..1689548 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MUW67_RS07955 (MUW67_07955) 1689562..1689864 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MUW67_RS07960 (MUW67_07960) 1689861..1690178 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MUW67_RS07965 (MUW67_07965) 1690175..1691179 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MUW67_RS07970 (MUW67_07970) 1691232..1692521 + 1290 WP_003902090.1 serine hydrolase domain-containing protein -
MUW67_RS07975 (MUW67_07975) 1692594..1693319 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
MUW67_RS07980 (MUW67_07980) 1693425..1693637 - 213 WP_003898900.1 dodecin family protein -
MUW67_RS07985 (MUW67_07985) 1693698..1694096 + 399 WP_003900351.1 hypothetical protein -
MUW67_RS07990 (MUW67_07990) 1694141..1695169 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T241096 WP_003407593.1 NZ_CP095022:1689861-1690178 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T241096 NZ_LT906476:2323615-2323911 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT241096 WP_003900349.1 NZ_CP095022:1689562-1689864 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT241096 NZ_LT906476:2323371-2323625 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References