Detailed information of TA system TA241092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384288..1384976
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: MUW67_RS06615
• Protein ID: WP_003406304.1
• Coordinates: 1384545..1384976 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: MUW67_RS06610
• Protein ID: WP_003406302.1
• Coordinates: 1384288..1384548 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS06590 (MUW67_06590)	1379865..1380689	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
MUW67_RS06595 (MUW67_06595)	1380694..1381875	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
MUW67_RS06600 (MUW67_06600)	1381952..1383052	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
MUW67_RS06605 (MUW67_06605)	1383223..1384212	+	990	WP_003406301.1	malate dehydrogenase	-
MUW67_RS06610 (MUW67_06610)	1384288..1384548	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
MUW67_RS06615 (MUW67_06615)	1384545..1384976	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW67_RS06620 (MUW67_06620)	1384999..1386582	-	1584	WP_009940130.1	PE family protein	-
MUW67_RS06625 (MUW67_06625)	1386762..1387622	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
MUW67_RS06630 (MUW67_06630)	1387703..1388533	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
MUW67_RS06635 (MUW67_06635)	1388590..1388883	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
MUW67_RS06640 (MUW67_06640)	1388880..1389149	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T241092 WP_003406304.1 NZ_CP095022:1384545-1384976 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T241092 NZ_LT906474:3658625-3658903 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT241092 WP_003406302.1 NZ_CP095022:1384288-1384548 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT241092 NZ_LT906474:3658362-3658622 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6