Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1229312..1229943 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MUW67_RS05890 Protein ID WP_003405820.1
Coordinates 1229312..1229623 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MUW67_RS05895 Protein ID WP_003405836.1
Coordinates 1229623..1229943 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS05870 (MUW67_05870) 1224793..1226217 - 1425 WP_003405805.1 class II fumarate hydratase -
MUW67_RS05875 (MUW67_05875) 1226248..1227336 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
MUW67_RS05880 (MUW67_05880) 1227392..1228036 + 645 WP_003915494.1 DUF4245 domain-containing protein -
MUW67_RS05885 (MUW67_05885) 1228043..1229200 - 1158 WP_003898727.1 AI-2E family transporter -
MUW67_RS05890 (MUW67_05890) 1229312..1229623 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MUW67_RS05895 (MUW67_05895) 1229623..1229943 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MUW67_RS05900 (MUW67_05900) 1229953..1231489 + 1537 Protein_1160 carboxylesterase/lipase family protein -
MUW67_RS05905 (MUW67_05905) 1231496..1232608 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MUW67_RS05910 (MUW67_05910) 1232618..1232875 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MUW67_RS05915 (MUW67_05915) 1232865..1234112 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MUW67_RS05920 (MUW67_05920) 1234109..1234747 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T241090 WP_003405820.1 NZ_CP095022:c1229623-1229312 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T241090 NZ_LT906474:c3587098-3586169 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAGCTGTTGATGGCTGCTCTGCCGCATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACGGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCTATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACAGTAAA
CCGGGGATTACCGCGATCCGACAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCAGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGTCGGTGTGCGAACGTGTGGAAATGGAGT
ATGGTTTCACCACTATGAGTGTCGTTTCTCTGGCGGATCTTTATGGCGGTAAAATCTGCGCGGCGCTTGATCGTCAACAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTCCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCGAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGGTGCTAAAAGATAAAAATCCTGCGAAGT
ATGTGGCGGCGGTGAGTAAGCTGGAGAGGGTTCTGGAGCAGTATTCTTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT241090 WP_003405836.1 NZ_CP095022:c1229943-1229623 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT241090 NZ_LT906474:c3587867-3587085 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAAAATGGCTGGCTCAGGCGCATCGCTCACGGCGTGTACTGCCGTACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTGCAAACACAGTGGGAAAAGTCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTACAGGGCCATGCGCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTTAA
GCTGCCGGGATGGTTTGCTGCCTTCGAACAATCTGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTAA
CGCCATTTACCACGGAACTGAAAATTGGCGACCGCCAGTTAGCAGGCAGTGCCCCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGTTGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTCTATCTTGCCCGGCGTAATGGACATCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTTCGGGAAAGCGGCAAATCATACCCGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References