Detailed information of TA system TA024109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4611196..4612534
• Replicon: chromosome
• Accession: NC_012962
• Organism: Photorhabdus asymbiotica

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: PAU_RS19620
• Protein ID: WP_015836031.1
• Coordinates: 4611196..4612146 (-)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: PAU_RS19625
• Protein ID: WP_015836032.1
• Coordinates: 4612139..4612534 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAU_RS19595	4607550..4607816	+	267	WP_015836028.1	helix-turn-helix domain-containing protein	-
PAU_RS19600	4607806..4608693	+	888	WP_041382500.1	hypothetical protein	-
PAU_RS19605	4609327..4610259	-	933	WP_121302549.1	IS3 family transposase	-
PAU_RS19610	4610169..4610675	-	507	WP_012776365.1	helix-turn-helix domain-containing protein	-
PAU_RS19615	4610720..4610878	-	159	WP_015836030.1	Arm DNA-binding domain-containing protein	-
PAU_RS19620	4611196..4612146	-	951	WP_015836031.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PAU_RS19625	4612139..4612534	-	396	WP_015836032.1	hypothetical protein	Antitoxin
PAU_RS19630	4612609..4613443	-	835	Protein_3879	DUF4942 domain-containing protein	-
PAU_RS19635	4613557..4613870	-	314	Protein_3880	toxin	-
PAU_RS19640	4613911..4614234	-	324	WP_015836035.1	type IV toxin-antitoxin system YeeU family antitoxin	-
PAU_RS19645	4614247..4614717	-	471	WP_015836036.1	DNA repair protein RadC	-
PAU_RS19650	4614783..4615604	-	822	WP_015836037.1	DUF945 domain-containing protein	-
PAU_RS19655	4615724..4616135	-	412	Protein_3884	hypothetical protein	-
PAU_RS19660	4616304..4616936	-	633	WP_015836040.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4605705..4638249	32544

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-303)

Antitoxin

• Protein of unknown function DUF6088 (7-114)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 36059.28 Da
• Isoelectric Point: 4.5989

>T24109 WP_015836031.1 NC_012962:c4612146-4611196 [Photorhabdus asymbiotica]
MDDLTKLFPDVADALGIESVAIVEKDHYIVELLRLLQPLSFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFSQ
QYSRGQRKDIRKGIIQTIIETITASGTFRMDEGYPKVTRDEYRYNEISVRYPQEYAQIPCLRPFIKLELMETGLLEAAEN
RVISSLVMDLTKKGEVVRAFPCATIASTQAEKLISMMRRTAASMSDVERVVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGDQYPEFCESPVEELKMGLEELESNPVYKERYLRFVTPMVFGESHVSWEDAYTCFRKTTLDVFDA

Nucleotide

• Length: 951 bp

>T24109 NC_012962:c4612146-4611196 [Photorhabdus asymbiotica]
ATGGATGATTTAACAAAGCTATTCCCGGACGTTGCCGATGCTCTAGGCATTGAATCAGTTGCAATTGTAGAGAAAGATCA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGTCCTTTGATACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTTCCTGTCGCCGGTTTTTCCCAG
CAATATTCCAGAGGCCAGCGTAAAGACATTCGTAAGGGTATTATTCAGACCATTATCGAAACGATTACAGCCTCAGGTAC
GTTTCGCATGGATGAAGGGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTTCGGTGCGCTACCCACAGG
AATATGCACAAATTCCCTGCTTAAGGCCATTTATTAAACTGGAACTGATGGAAACGGGTTTGCTTGAGGCTGCGGAAAAC
CGTGTTATTAGCTCATTGGTAATGGATCTAACAAAGAAGGGTGAAGTAGTGAGGGCTTTTCCCTGCGCAACTATCGCCAG
CACGCAGGCTGAAAAGCTGATTTCGATGATGCGCAGAACGGCTGCAAGTATGAGTGATGTGGAACGTGTAGTAGATGAAT
CATTGGTGCGTCATATCTACGACAATTTTTGTATTGTTAGAGAAAAAGGTGCTGATGTTCCTGTTTTAAAGCAATTCGTG
CAGGAATGCATTGAGCAGGATATTGAACGTTACGGTGACCAGTATCCTGAATTCTGCGAGTCGCCTGTTGAAGAACTAAA
AATGGGGCTGGAAGAACTTGAGAGCAATCCTGTTTATAAGGAACGCTATCTGCGGTTCGTCACACCAATGGTATTCGGTG
AAAGCCACGTTTCATGGGAAGATGCCTATACCTGCTTCCGCAAAACGACATTGGATGTGTTTGATGCATAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14395.76 Da
• Isoelectric Point: 11.1490

>AT24109 WP_015836032.1 NC_012962:c4612534-4612139 [Photorhabdus asymbiotica]
MTIKARIQSRLKRSKRYVFTRDNFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSVAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Nucleotide

• Length: 396 bp

>AT24109 NC_012962:c4612534-4612139 [Photorhabdus asymbiotica]
ATGACCATAAAAGCTCGTATTCAGTCACGGCTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACAATTTCAAAGATCT
TGCTGGCTACGATCAAATTGGCAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAACTGCTGAAAGTAGGTTATGGCGTCT
ACACCAAAGCGCGGCAAAATGCGATTACCGGTAAGCTGATGCCTGCTGCTCCCGGAGGTTCTGTTGCGGTAATGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGTCTGGCAGGAGCAACAAGTGCTTACAACAGTGGTAAATCTACCCAGATCCC
CGCGTCACTTGAAATCAAAACCTCACCACGTTTTAAGAGAACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA