Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1013273..1013892 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MUW67_RS04815 Protein ID WP_003404726.1
Coordinates 1013458..1013892 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag MUW67_RS04810 Protein ID WP_003898641.1
Coordinates 1013273..1013452 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS04795 (MUW67_04795) 1008746..1010326 + 1581 WP_003910977.1 serine hydrolase -
MUW67_RS04800 (MUW67_04800) 1010323..1012716 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
MUW67_RS04805 (MUW67_04805) 1012989..1013147 + 159 WP_003404720.1 hypothetical protein -
MUW67_RS04810 (MUW67_04810) 1013273..1013452 + 180 WP_003898641.1 antitoxin Antitoxin
MUW67_RS04815 (MUW67_04815) 1013458..1013892 + 435 WP_003404726.1 SRPBCC family protein Toxin
MUW67_RS04820 (MUW67_04820) 1013990..1014763 + 774 WP_003404735.1 VOC family protein -
MUW67_RS04825 (MUW67_04825) 1014828..1015277 + 450 WP_003404738.1 hypothetical protein -
MUW67_RS04830 (MUW67_04830) 1015412..1015642 - 231 WP_003898642.1 hypothetical protein -
MUW67_RS04835 (MUW67_04835) 1015809..1017317 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
MUW67_RS04840 (MUW67_04840) 1017319..1018557 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T241088 WP_003404726.1 NZ_CP095022:1013458-1013892 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T241088 NZ_LT906474:2633353-2633460 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT241088 WP_003898641.1 NZ_CP095022:1013273-1013452 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT241088 NZ_LT906474:c2633303-2633240 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References