Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 751871..752504 | Replicon | chromosome |
Accession | NZ_CP095022 | ||
Organism | Mycobacterium tuberculosis strain SGF0472017 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQD6 |
Locus tag | MUW67_RS03465 | Protein ID | WP_003403365.1 |
Coordinates | 751871..752254 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ56 |
Locus tag | MUW67_RS03470 | Protein ID | WP_003403368.1 |
Coordinates | 752349..752504 (-) | Length | 52 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MUW67_RS03440 (MUW67_03440) | 747163..747699 | + | 537 | WP_003403341.1 | 50S ribosomal protein L10 | - |
MUW67_RS03445 (MUW67_03445) | 747736..748128 | + | 393 | WP_003403353.1 | 50S ribosomal protein L7/L12 | - |
MUW67_RS03450 (MUW67_03450) | 748121..748816 | - | 696 | WP_003403355.1 | TetR/AcrR family transcriptional regulator | - |
MUW67_RS03455 (MUW67_03455) | 748887..750392 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
MUW67_RS03460 (MUW67_03460) | 750473..751483 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
MUW67_RS03465 (MUW67_03465) | 751871..752254 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | Toxin |
MUW67_RS03470 (MUW67_03470) | 752349..752504 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MUW67_RS03475 (MUW67_03475) | 752580..753296 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
MUW67_RS03480 (MUW67_03480) | 753572..753880 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
MUW67_RS03485 (MUW67_03485) | 753867..754112 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | - |
MUW67_RS03490 (MUW67_03490) | 754222..754659 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
MUW67_RS03495 (MUW67_03495) | 754656..754910 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
MUW67_RS03500 (MUW67_03500) | 755024..757387 | + | 2364 | WP_003901895.1 | arylsulfatase AtsD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 13959.73 Da Isoelectric Point: 6.0803
>T241083 WP_003403365.1 NZ_CP095022:c752254-751871 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD
Download Length: 384 bp
>T241083 NZ_LT906474:2272696-2272983 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTAAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTAAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 52 a.a. Molecular weight: 5872.72 Da Isoelectric Point: 5.7734
>AT241083 WP_003403368.1 NZ_CP095022:c752504-752349 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE
Download Length: 156 bp
>AT241083 NZ_LT906474:2272457-2272696 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSF8 |