Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751871..752504 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag MUW67_RS03465 Protein ID WP_003403365.1
Coordinates 751871..752254 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag MUW67_RS03470 Protein ID WP_003403368.1
Coordinates 752349..752504 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS03440 (MUW67_03440) 747163..747699 + 537 WP_003403341.1 50S ribosomal protein L10 -
MUW67_RS03445 (MUW67_03445) 747736..748128 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
MUW67_RS03450 (MUW67_03450) 748121..748816 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
MUW67_RS03455 (MUW67_03455) 748887..750392 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
MUW67_RS03460 (MUW67_03460) 750473..751483 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MUW67_RS03465 (MUW67_03465) 751871..752254 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
MUW67_RS03470 (MUW67_03470) 752349..752504 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW67_RS03475 (MUW67_03475) 752580..753296 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MUW67_RS03480 (MUW67_03480) 753572..753880 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUW67_RS03485 (MUW67_03485) 753867..754112 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
MUW67_RS03490 (MUW67_03490) 754222..754659 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
MUW67_RS03495 (MUW67_03495) 754656..754910 - 255 WP_003911263.1 antitoxin VapB7 -
MUW67_RS03500 (MUW67_03500) 755024..757387 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T241083 WP_003403365.1 NZ_CP095022:c752254-751871 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T241083 NZ_LT906474:2272696-2272983 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTAAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT241083 WP_003403368.1 NZ_CP095022:c752504-752349 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT241083 NZ_LT906474:2272457-2272696 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References