Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 716379..717043 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag MUW67_RS03295 Protein ID WP_003403246.1
Coordinates 716636..717043 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag MUW67_RS03290 Protein ID WP_003403244.1
Coordinates 716379..716639 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS03265 (MUW67_03265) 712556..713620 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW67_RS03270 (MUW67_03270) 713724..714671 + 948 WP_003403232.1 DUF732 domain-containing protein -
MUW67_RS03275 (MUW67_03275) 714764..715018 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
MUW67_RS03280 (MUW67_03280) 715018..715413 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
MUW67_RS03285 (MUW67_03285) 715507..716247 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
MUW67_RS03290 (MUW67_03290) 716379..716639 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUW67_RS03295 (MUW67_03295) 716636..717043 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW67_RS03300 (MUW67_03300) 717115..718266 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MUW67_RS03305 (MUW67_03305) 718359..720086 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T241082 WP_003403246.1 NZ_CP095022:716636-717043 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T241082 NZ_LT906474:1987320-1987423 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT241082 WP_003403244.1 NZ_CP095022:716379-716639 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT241082 NZ_LT906474:c1987461-1987190 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References