Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709136..709761 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MUW67_RS03245 Protein ID WP_003403218.1
Coordinates 709360..709761 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MUW67_RS03240 Protein ID WP_003403213.1
Coordinates 709136..709363 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS03215 (MUW67_03215) 704315..704536 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MUW67_RS03220 (MUW67_03220) 704678..705283 + 606 WP_003898526.1 hypothetical protein -
MUW67_RS03225 (MUW67_03225) 705302..707869 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
MUW67_RS03230 (MUW67_03230) 707953..708702 + 750 WP_003898528.1 hypothetical protein -
MUW67_RS03235 (MUW67_03235) 708699..708941 + 243 WP_003403210.1 hypothetical protein -
MUW67_RS03240 (MUW67_03240) 709136..709363 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MUW67_RS03245 (MUW67_03245) 709360..709761 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MUW67_RS03250 (MUW67_03250) 709890..709973 + 84 Protein_643 galactose-1-phosphate uridylyltransferase -
MUW67_RS03255 (MUW67_03255) 709992..711073 + 1082 Protein_644 galactose-1-phosphate uridylyltransferase -
MUW67_RS03260 (MUW67_03260) 711070..712161 + 1092 WP_003900977.1 galactokinase -
MUW67_RS03265 (MUW67_03265) 712556..713620 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW67_RS03270 (MUW67_03270) 713724..714671 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T241080 WP_003403218.1 NZ_CP095022:709360-709761 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T241080 NZ_CP095022:709360-709761 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT241080 WP_003403213.1 NZ_CP095022:709136-709363 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT241080 NZ_CP095022:709136-709363 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References