Detailed information of TA system TA241079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 701598..702241
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUW67_RS03195
• Protein ID: WP_031724455.1
• Coordinates: 701840..702241 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ91
• Locus tag: MUW67_RS03190
• Protein ID: WP_003403184.1
• Coordinates: 701598..701843 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS03155 (MUW67_03155)	696878..697408	-	531	WP_003917320.1	two component system sensor kinase HK2	-
MUW67_RS03160 (MUW67_03160)	697392..698087	-	696	WP_003918099.1	two-component system response regulator TcrA	-
MUW67_RS03165 (MUW67_03165)	698210..698521	+	312	WP_003403164.1	hypothetical protein	-
MUW67_RS03170 (MUW67_03170)	698593..699543	+	951	WP_003900184.1	DUF1259 domain-containing protein	-
MUW67_RS03175 (MUW67_03175)	699784..700368	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
MUW67_RS03180 (MUW67_03180)	700370..701080	+	711	Protein_629	IS607 family element RNA-guided endonuclease TnpB	-
MUW67_RS03185 (MUW67_03185)	701083..701553	+	471	WP_003898523.1	hypothetical protein	-
MUW67_RS03190 (MUW67_03190)	701598..701843	+	246	WP_003403184.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MUW67_RS03195 (MUW67_03195)	701840..702241	+	402	WP_031724455.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW67_RS03200 (MUW67_03200)	702232..702411	+	180	Protein_633	hypothetical protein	-
MUW67_RS03205 (MUW67_03205)	702829..703026	-	198	WP_003403191.1	hypothetical protein	-
MUW67_RS03210 (MUW67_03210)	703106..704263	-	1158	WP_003898524.1	hypothetical protein	-
MUW67_RS03215 (MUW67_03215)	704315..704536	-	222	WP_003898525.1	DUF4926 domain-containing protein	-
MUW67_RS03220 (MUW67_03220)	704678..705283	+	606	WP_003898526.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14459.13 Da
• Isoelectric Point: 4.4463

>T241079 WP_031724455.1 NZ_CP095022:701840-702241 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADGRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Nucleotide

• Length: 402 bp

>T241079 NZ_LT906474:1017276-1017611 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8813.12 Da
• Isoelectric Point: 10.3486

>AT241079 WP_003403184.1 NZ_CP095022:701598-701843 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Nucleotide

• Length: 246 bp

>AT241079 NZ_LT906474:1017028-1017276 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: G0TQ91