Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 442552..443563 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MUW67_RS01930 Protein ID WP_003401859.1
Coordinates 442552..443145 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MUW67_RS01935 Protein ID WP_003401860.1
Coordinates 443174..443563 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS01910 (MUW67_01910) 438201..439583 + 1383 WP_003898415.1 magnesium transporter -
MUW67_RS01915 (MUW67_01915) 439595..440629 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MUW67_RS01920 (MUW67_01920) 440725..441408 + 684 WP_003401857.1 VTT domain-containing protein -
MUW67_RS01925 (MUW67_01925) 441397..442527 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MUW67_RS01930 (MUW67_01930) 442552..443145 - 594 WP_003401859.1 zeta toxin family protein Toxin
MUW67_RS01935 (MUW67_01935) 443174..443563 - 390 WP_003401860.1 hypothetical protein Antitoxin
MUW67_RS01940 (MUW67_01940) 443644..444855 - 1212 WP_003401861.1 VWA domain-containing protein -
MUW67_RS01945 (MUW67_01945) 444861..445463 - 603 WP_003898417.1 SRPBCC family protein -
MUW67_RS01950 (MUW67_01950) 445477..446373 - 897 WP_003898418.1 MoxR family ATPase -
MUW67_RS01955 (MUW67_01955) 446370..446963 - 594 WP_003401864.1 NTP transferase domain-containing protein -
MUW67_RS01960 (MUW67_01960) 446960..447718 - 759 WP_244753784.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T241074 WP_003401859.1 NZ_CP095022:c443145-442552 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T241074 NZ_LT906473:c2909769-2909509 [Corynebacterium cystitidis]
ATGAAAACCATATCTTTTACAGAATCACGCAATAACTACGCAGCTGTTATGGATTCCGTTATTGATGATCGGGAACCTGT
CGTTATTACGCGTACCGGACGTGATCCAGTTGTCATGATCGCTCTAGATGATTACAACTCTCTGCAAGAAACTGCGTATC
TTATGCGCTCGCCGGAAAACAGCAAACGCTTACGTGAATCCATCGCGGAGCTTGAAGCTGGCGGTGGTGTTGTCCACGAG
CTGCTCGACGAAGAGGCATAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT241074 WP_003401860.1 NZ_CP095022:c443563-443174 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT241074 NZ_LT906473:c2909498-2909244 [Corynebacterium cystitidis]
ATGAATATTTCCTGGTCCACACACGCCTGGGAAGACTATGTGTGGTGGCAGCAGCATGACCGTAAAATGTTGAAGCGAAT
CAACCAGTTGATCCGCGATATTATCCGCAACGGCACTAGAGGCATCGGAAAACCGGAGCCTCTAAAGCATGATTTCAGTG
GCTATTGGTCTCGACGCATCAATGAAGAGCACCGGTTGATCTATTCGATCCAGGATTCGACGATATTCATCGCCGGGTGT
CGGTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References