Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 362240..362883 Replicon chromosome
Accession NZ_CP095022
Organism Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MUW67_RS01595 Protein ID WP_003401566.1
Coordinates 362458..362883 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MUW67_RS01590 Protein ID WP_003401563.1
Coordinates 362240..362461 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW67_RS01565 (MUW67_01565) 357360..358163 - 804 WP_003401540.1 Stf0 family sulphotransferase -
MUW67_RS01570 (MUW67_01570) 358173..359570 - 1398 WP_003401544.1 sulfatase -
MUW67_RS01575 (MUW67_01575) 359749..361523 + 1775 Protein_310 PE family protein -
MUW67_RS01580 (MUW67_01580) 361666..361893 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MUW67_RS01585 (MUW67_01585) 361890..362192 + 303 WP_003401560.1 toxin-antitoxin system toxin -
MUW67_RS01590 (MUW67_01590) 362240..362461 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MUW67_RS01595 (MUW67_01595) 362458..362883 + 426 WP_003401566.1 PIN domain nuclease Toxin
MUW67_RS01600 (MUW67_01600) 363019..363651 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
MUW67_RS01605 (MUW67_01605) 363648..364556 + 909 WP_003900117.1 protochlorophyllide reductase -
MUW67_RS01610 (MUW67_01610) 364564..365154 - 591 WP_229298012.1 hypothetical protein -
MUW67_RS01615 (MUW67_01615) 365147..365197 - 51 Protein_318 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T241073 WP_003401566.1 NZ_CP095022:362458-362883 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T241073 NZ_LT906473:c2909498-2909244 [Corynebacterium cystitidis]
ATGAATATTTCCTGGTCCACACACGCCTGGGAAGACTATGTGTGGTGGCAGCAGCATGACCGTAAAATGTTGAAGCGAAT
CAACCAGTTGATCCGCGATATTATCCGCAACGGCACTAGAGGCATCGGAAAACCGGAGCCTCTAAAGCATGATTTCAGTG
GCTATTGGTCTCGACGCATCAATGAAGAGCACCGGTTGATCTATTCGATCCAGGATTCGACGATATTCATCGCCGGGTGT
CGGTATCACTACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT241073 WP_003401563.1 NZ_CP095022:362240-362461 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT241073 NZ_LT906473:c2909769-2909509 [Corynebacterium cystitidis]
ATGAAAACCATATCTTTTACAGAATCACGCAATAACTACGCAGCTGTTATGGATTCCGTTATTGATGATCGGGAACCTGT
CGTTATTACGCGTACCGGACGTGATCCAGTTGTCATGATCGCTCTAGATGATTACAACTCTCTGCAAGAAACTGCGTATC
TTATGCGCTCGCCGGAAAACAGCAAACGCTTACGTGAATCCATCGCGGAGCTTGAAGCTGGCGGTGGTGTTGTCCACGAG
CTGCTCGACGAAGAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References