Detailed information of TA system TA241071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 361666..362192
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: MUW67_RS01585
• Protein ID: WP_003401560.1
• Coordinates: 361890..362192 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: MUW67_RS01580
• Protein ID: WP_003401555.1
• Coordinates: 361666..361893 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS01565 (MUW67_01565)	357360..358163	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
MUW67_RS01570 (MUW67_01570)	358173..359570	-	1398	WP_003401544.1	sulfatase	-
MUW67_RS01575 (MUW67_01575)	359749..361523	+	1775	Protein_310	PE family protein	-
MUW67_RS01580 (MUW67_01580)	361666..361893	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
MUW67_RS01585 (MUW67_01585)	361890..362192	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
MUW67_RS01590 (MUW67_01590)	362240..362461	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
MUW67_RS01595 (MUW67_01595)	362458..362883	+	426	WP_003401566.1	PIN domain nuclease	-
MUW67_RS01600 (MUW67_01600)	363019..363651	+	633	WP_003905275.1	TetR/AcrR family transcriptional regulator	-
MUW67_RS01605 (MUW67_01605)	363648..364556	+	909	WP_003900117.1	protochlorophyllide reductase	-
MUW67_RS01610 (MUW67_01610)	364564..365154	-	591	WP_229298012.1	hypothetical protein	-
MUW67_RS01615 (MUW67_01615)	365147..365197	-	51	Protein_318	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T241071 WP_003401560.1 NZ_CP095022:361890-362192 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T241071 NZ_LT906473:c2166056-2165895 [Corynebacterium cystitidis]
ATGCGAATTCACGTCGGCCCTGGCTATCGGATCTACTACATGGCAAGAGGAAACCAAATCATGCTGCTAGTCATTGGCGG
CGATAAATCCACCCAGCAGCGTGACATAGCAAAAGCTAAACGCCTTGCAACAGAAATTATTAAGGAGGGATCATGGGAGT
AA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT241071 WP_003401555.1 NZ_CP095022:361666-361893 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT241071 NZ_LT906473:c2165904-2165611 [Corynebacterium cystitidis]
ATGGGAGTAAAGATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAAGAAGATATTGCTGCCTACCTGAACGCAGC
ACTCGAAGATGGCGACCCGGCTCTCTGGCAGGCCGCACTTGGTGATGTCGCCAAAGCGCGTGGTATGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGAAACCCGTCCTGGCAGACCGTCACAAAG
GTTCTCGCTGCACTCGGACTGAAGGTCGAAGTCAAAGCCAACGCTTTAGCGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1