Detailed information of TA system TA241070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 73140..73773
• Replicon: chromosome
• Accession: NZ_CP095022
• Organism: Mycobacterium tuberculosis strain SGF0472017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUW67_RS00365
• Protein ID: WP_031724476.1
• Coordinates: 73372..73773 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P0CW29
• Locus tag: MUW67_RS00360
• Protein ID: WP_003400577.1
• Coordinates: 73140..73379 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW67_RS00345 (MUW67_00345)	68436..69876	+	1441	Protein_65	FAD-binding oxidoreductase	-
MUW67_RS00350 (MUW67_00350)	69932..70093	+	162	WP_003899796.1	hypothetical protein	-
MUW67_RS00355 (MUW67_00355)	70134..73073	+	2940	WP_003901785.1	UPF0182 family protein	-
MUW67_RS00360 (MUW67_00360)	73140..73379	+	240	WP_003400577.1	antitoxin VapB1	Antitoxin
MUW67_RS00365 (MUW67_00365)	73372..73773	+	402	WP_031724476.1	type II toxin-antitoxin system ribonuclease VapC1	Toxin
MUW67_RS00370 (MUW67_00370)	73825..76062	-	2238	WP_003899797.1	NADP-dependent isocitrate dehydrogenase	-
MUW67_RS00375 (MUW67_00375)	76180..76749	-	570	WP_003400591.1	TetR/AcrR family transcriptional regulator	-
MUW67_RS00380 (MUW67_00380)	76852..77763	+	912	WP_003899798.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (36-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14311.39 Da
• Isoelectric Point: 4.8887

>T241070 WP_031724476.1 NZ_CP095022:73372-73773 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIALRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Nucleotide

• Length: 402 bp

>T241070 NZ_LT906473:c2165904-2165611 [Corynebacterium cystitidis]
ATGGGAGTAAAGATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAAGAAGATATTGCTGCCTACCTGAACGCAGC
ACTCGAAGATGGCGACCCGGCTCTCTGGCAGGCCGCACTTGGTGATGTCGCCAAAGCGCGTGGTATGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGAAACCCGTCCTGGCAGACCGTCACAAAG
GTTCTCGCTGCACTCGGACTGAAGGTCGAAGTCAAAGCCAACGCTTTAGCGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.84 Da
• Isoelectric Point: 8.5960

>AT241070 WP_003400577.1 NZ_CP095022:73140-73379 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Nucleotide

• Length: 240 bp

>AT241070 NZ_LT906473:c2166056-2165895 [Corynebacterium cystitidis]
ATGCGAATTCACGTCGGCCCTGGCTATCGGATCTACTACATGGCAAGAGGAAACCAAATCATGCTGCTAGTCATTGGCGG
CGATAAATCCACCCAGCAGCGTGACATAGCAAAAGCTAAACGCCTTGCAACAGAAATTATTAAGGAGGGATCATGGGAGT
AA

Structures

Antitoxin

• AlphaFold DB: A0A829CHM7