Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3764918..3765447 | Replicon | chromosome |
| Accession | NZ_CP095021 | ||
| Organism | Mycobacterium tuberculosis strain SGF0422017 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | MUW66_RS17715 | Protein ID | WP_003417760.1 |
| Coordinates | 3765190..3765447 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | MUW66_RS17710 | Protein ID | WP_003417757.1 |
| Coordinates | 3764918..3765193 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW66_RS17675 (MUW66_17675) | 3761491..3762180 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| MUW66_RS17680 (MUW66_17680) | 3762367..3762738 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| MUW66_RS17685 (MUW66_17685) | 3762636..3762854 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| MUW66_RS17690 (MUW66_17690) | 3762881..3763141 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| MUW66_RS17695 (MUW66_17695) | 3763256..3763645 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| MUW66_RS17700 (MUW66_17700) | 3763659..3763952 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| MUW66_RS17705 (MUW66_17705) | 3763949..3764794 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| MUW66_RS17710 (MUW66_17710) | 3764918..3765193 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| MUW66_RS17715 (MUW66_17715) | 3765190..3765447 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUW66_RS17720 (MUW66_17720) | 3765489..3766679 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| MUW66_RS17725 (MUW66_17725) | 3766796..3767164 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| MUW66_RS17730 (MUW66_17730) | 3767161..3767712 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| MUW66_RS17735 (MUW66_17735) | 3767719..3768300 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| MUW66_RS17740 (MUW66_17740) | 3768281..3768649 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| MUW66_RS17745 (MUW66_17745) | 3768627..3769019 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T241067 WP_003417760.1 NZ_CP095021:3765190-3765447 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T241067 NZ_LT906471:c2808434-2808183 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT241067 WP_003417757.1 NZ_CP095021:3764918-3765193 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT241067 NZ_LT906471:c2808180-2807779 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|