Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3116904..3118678 | Replicon | chromosome |
| Accession | NZ_CP095021 | ||
| Organism | Mycobacterium tuberculosis strain SGF0422017 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | MUW66_RS14875 | Protein ID | WP_003414409.1 |
| Coordinates | 3116904..3117788 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | MUW66_RS14880 | Protein ID | WP_003414414.1 |
| Coordinates | 3117791..3118678 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW66_RS14855 (MUW66_14855) | 3112159..3112533 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| MUW66_RS14860 (MUW66_14860) | 3112530..3114968 | - | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| MUW66_RS14865 (MUW66_14865) | 3114965..3115753 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| MUW66_RS14870 (MUW66_14870) | 3116087..3116632 | - | 546 | WP_014584866.1 | DUF1802 family protein | - |
| MUW66_RS14875 (MUW66_14875) | 3116904..3117788 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| MUW66_RS14880 (MUW66_14880) | 3117791..3118678 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| MUW66_RS14885 (MUW66_14885) | 3118983..3119528 | - | 546 | WP_003910939.1 | DUF1802 family protein | - |
| MUW66_RS14890 (MUW66_14890) | 3119525..3119794 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| MUW66_RS14895 (MUW66_14895) | 3119815..3120207 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW66_RS14900 (MUW66_14900) | 3120204..3120419 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MUW66_RS14905 (MUW66_14905) | 3120466..3121215 | + | 750 | WP_003902358.1 | enoyl-CoA hydratase | - |
| MUW66_RS14910 (MUW66_14910) | 3121294..3122376 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T241061 WP_003414409.1 NZ_CP095021:c3117788-3116904 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T241061 NZ_LT906464:c1585518-1585165 [Staphylococcus muscae]
ATGAAGCGCGGTGATGTATACTTAGCTGATTTATCACCAGTACAGGGTTCTGAACAAGGGGGAGTTAGACCCGTCGTAAT
CATACAAAATGATACTGGTAACAAATATAGTCCGACTGTGATTGTAGCGGCAATTACTGGACGTATTAATAAAGCGAAGA
TTCCAACACATGTAGAAATTGAAAAAAAGAAATACAAACTGGACAAAGATTCTGTTATTTTGTTAGAACAGATTCGGACA
GTTGATAAAAATCGATTGAAAGAAAAACTGACTTTTTTATCGGACGAAAAGATGAAAGAAGTAAACAATGCACTCGGTAT
CAGTCTAGGGTTACAAGTGGTTCAATCACGATAA
ATGAAGCGCGGTGATGTATACTTAGCTGATTTATCACCAGTACAGGGTTCTGAACAAGGGGGAGTTAGACCCGTCGTAAT
CATACAAAATGATACTGGTAACAAATATAGTCCGACTGTGATTGTAGCGGCAATTACTGGACGTATTAATAAAGCGAAGA
TTCCAACACATGTAGAAATTGAAAAAAAGAAATACAAACTGGACAAAGATTCTGTTATTTTGTTAGAACAGATTCGGACA
GTTGATAAAAATCGATTGAAAGAAAAACTGACTTTTTTATCGGACGAAAAGATGAAAGAAGTAAACAATGCACTCGGTAT
CAGTCTAGGGTTACAAGTGGTTCAATCACGATAA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT241061 WP_003414414.1 NZ_CP095021:c3118678-3117791 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT241061 NZ_LT906464:c1585689-1585519 [Staphylococcus muscae]
ATGTCAGTATTCAATCAAGTAAAATTTAAAAATTTAGAGCAGTCATTAAAAGAAGGTTATGCACAAATGGCTGATCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAGGCGTGCGATTGTAATGAATCTCACTTACTATCAAAGCATC
AGGATGATTAA
ATGTCAGTATTCAATCAAGTAAAATTTAAAAATTTAGAGCAGTCATTAAAAGAAGGTTATGCACAAATGGCTGATCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAGGCGTGCGATTGTAATGAATCTCACTTACTATCAAAGCATC
AGGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|