Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3099617..3100187 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MUW66_RS14770 Protein ID WP_003414166.1
Coordinates 3099617..3099973 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MUW66_RS14775 Protein ID WP_003901465.1
Coordinates 3099957..3100187 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS14750 (MUW66_14750) 3095083..3096771 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
MUW66_RS14755 (MUW66_14755) 3096775..3097101 - 327 WP_003414157.1 hypothetical protein -
MUW66_RS14760 (MUW66_14760) 3097274..3097861 + 588 WP_003914429.1 DUF3558 family protein -
MUW66_RS14765 (MUW66_14765) 3097880..3099515 + 1636 Protein_2915 CocE/NonD family hydrolase -
MUW66_RS14770 (MUW66_14770) 3099617..3099973 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MUW66_RS14775 (MUW66_14775) 3099957..3100187 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
MUW66_RS14780 (MUW66_14780) 3100230..3101273 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
MUW66_RS14785 (MUW66_14785) 3101272..3101739 + 468 WP_003414177.1 DUF1778 domain-containing protein -
MUW66_RS14790 (MUW66_14790) 3101915..3102169 - 255 WP_003917684.1 hypothetical protein -
MUW66_RS14795 (MUW66_14795) 3102317..3102721 + 405 WP_003414181.1 hypothetical protein -
MUW66_RS14800 (MUW66_14800) 3102718..3102909 + 192 WP_003414184.1 hypothetical protein -
MUW66_RS14805 (MUW66_14805) 3103126..3103386 + 261 Protein_2923 transposase -
MUW66_RS14810 (MUW66_14810) 3104496..3104753 + 258 WP_003899489.1 hypothetical protein -
MUW66_RS14815 (MUW66_14815) 3104858..3105169 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T241060 WP_003414166.1 NZ_CP095021:c3099973-3099617 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T241060 NZ_LT906464:c1437300-1437142 [Staphylococcus muscae]
ATGAATAAACAAGAAAATGAACATGGCATGGTTGACAGCTTTGAAGAAGTTGTTGAGTTAGGAAAAGAGATGGAACAAAT
CTCTGAAGAAAACGATGAACAAAAATATGAACAACCACATGAAGAAGCGGTTCGTAGTGATCGCGAAACAGATAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT241060 WP_003901465.1 NZ_CP095021:c3100187-3099957 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT241060 NZ_LT906464:c1437918-1437319 [Staphylococcus muscae]
ATGGCAATGAACTTTAAAATTTTCAAGGATCAAGAAACGGCTGCAACGTTTGTAGCGGATATTTTAAGAAAGCAATTCAA
TAATAATCCAACAACAATTGCAGGAATTCATTTAAAAAATGACAATGTACCTGTAAGTGCGGCATTACAAGAAAATGTTG
AGAAAAACCCAGTTGATTTCAGTCAAATTCATATTTTAGATTATGATAATCAAACGAACTACTACAAAGCATTAGGTGTA
CCCGAGAAACAAATTCACGAAATCCCAGAAGATGAAAAAGTAGAAGCATTCATCAAGCATCATGCAAAAACAAAAGAAAA
TAAAGGTAAGCTAACGTTACAAGTCGTGACAATCGATACAGATGGAAGTATTGGTATTCCAATGAATGATGCGGTGTTAA
CGGCACGTGAAATCGTTCTTGTATTAACAGGTGCTGAAAAAGCTGAAGTTACACGTAAATTATACGAAGAAAATGGCAGC
ACAACATTTATCCCATCAAGTTTAAAATCTCATCGCATGGTCAATGTTGTTTTAGATGAGGCAGCAGCACAAGGCTTACC
AGAAGATGTTAGAACTTATTTCTCAGTACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References