Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3059634..3060313 | Replicon | chromosome |
| Accession | NZ_CP095021 | ||
| Organism | Mycobacterium tuberculosis strain SGF0422017 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | MUW66_RS14540 | Protein ID | WP_003414059.1 |
| Coordinates | 3059634..3060050 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | MUW66_RS14545 | Protein ID | WP_003414061.1 |
| Coordinates | 3060047..3060313 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW66_RS14515 (MUW66_14515) | 3055686..3056588 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| MUW66_RS14520 (MUW66_14520) | 3056657..3057409 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| MUW66_RS14530 (MUW66_14530) | 3057653..3057928 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| MUW66_RS14535 (MUW66_14535) | 3057925..3059547 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| MUW66_RS14540 (MUW66_14540) | 3059634..3060050 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| MUW66_RS14545 (MUW66_14545) | 3060047..3060313 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MUW66_RS14550 (MUW66_14550) | 3060339..3060734 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW66_RS14555 (MUW66_14555) | 3060731..3061000 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MUW66_RS14560 (MUW66_14560) | 3061010..3062104 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| MUW66_RS14565 (MUW66_14565) | 3062101..3062520 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| MUW66_RS14570 (MUW66_14570) | 3062519..3062593 | + | 75 | Protein_2876 | hypothetical protein | - |
| MUW66_RS14575 (MUW66_14575) | 3062594..3063073 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| MUW66_RS14580 (MUW66_14580) | 3063144..3063944 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| MUW66_RS14585 (MUW66_14585) | 3064100..3064837 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T241058 WP_003414059.1 NZ_CP095021:c3060050-3059634 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T241058 NZ_LT906462:680913-681284 [Mammaliicoccus stepanovicii]
ATGAGAAGAGGAGATGTGTATCTCGCAGATCTTTCACCAGTTACTGGTTCTGAACAAGGGGGAACAAGACCAGTCGTGAT
TATACAAAATGATACCGGAAATAGATACAGTCCAACTGTCATTGTAGCAGCGATAACTGGGAAGATTAACAAAGCCAAAA
TACCTACACACGTAGAAATTGAAGCAGCGAAATACAAATTAGATAGAGATTCAGTTATTTTACTTGAACAGATAAGAACA
ATCGATAAAAAACGTTTAAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATTTAGCAATTGCAAT
CAGCCTCAATCTCACTTTGCAACATAAGTTTGATACATTAGGTAATACATAA
ATGAGAAGAGGAGATGTGTATCTCGCAGATCTTTCACCAGTTACTGGTTCTGAACAAGGGGGAACAAGACCAGTCGTGAT
TATACAAAATGATACCGGAAATAGATACAGTCCAACTGTCATTGTAGCAGCGATAACTGGGAAGATTAACAAAGCCAAAA
TACCTACACACGTAGAAATTGAAGCAGCGAAATACAAATTAGATAGAGATTCAGTTATTTTACTTGAACAGATAAGAACA
ATCGATAAAAAACGTTTAAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATTTAGCAATTGCAAT
CAGCCTCAATCTCACTTTGCAACATAAGTTTGATACATTAGGTAATACATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT241058 WP_003414061.1 NZ_CP095021:c3060313-3060047 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT241058 NZ_LT906462:680745-680912 [Mammaliicoccus stepanovicii]
ATGACATCTTTAACACAAAATCGCACGCAAAATTTAGAACAAACGCTTAAAGAAGGATATCGTTCTATGGCAGATTTGAA
CCTCTCCCTTGCATCTGAAGCATACTATAGTGAATGTGAAGCATGTGATTCAAATGAGTCGCATTTGACATCTTCAAACG
GTGAATAA
ATGACATCTTTAACACAAAATCGCACGCAAAATTTAGAACAAACGCTTAAAGAAGGATATCGTTCTATGGCAGATTTGAA
CCTCTCCCTTGCATCTGAAGCATACTATAGTGAATGTGAAGCATGTGATTCAAATGAGTCGCATTTGACATCTTCAAACG
GTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|