Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2920586..2921300 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MUW66_RS13715 Protein ID WP_003413460.1
Coordinates 2920860..2921300 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MUW66_RS13710 Protein ID WP_003413456.1
Coordinates 2920586..2920873 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS13675 (MUW66_13675) 2916008..2916253 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MUW66_RS13680 (MUW66_13680) 2916250..2916654 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
MUW66_RS13685 (MUW66_13685) 2916871..2917491 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MUW66_RS13690 (MUW66_13690) 2917502..2917996 + 495 WP_003413444.1 DUF2617 family protein -
MUW66_RS13695 (MUW66_13695) 2917993..2918424 + 432 WP_003899390.1 DUF4247 domain-containing protein -
MUW66_RS13700 (MUW66_13700) 2918449..2918907 + 459 WP_003413451.1 DUF350 domain-containing protein -
MUW66_RS13705 (MUW66_13705) 2918904..2920475 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MUW66_RS13710 (MUW66_13710) 2920586..2920873 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MUW66_RS13715 (MUW66_13715) 2920860..2921300 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW66_RS13720 (MUW66_13720) 2921321..2922076 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MUW66_RS13725 (MUW66_13725) 2922209..2922805 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MUW66_RS13730 (MUW66_13730) 2922813..2923658 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MUW66_RS13735 (MUW66_13735) 2923687..2924586 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MUW66_RS13740 (MUW66_13740) 2924714..2925388 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T241056 WP_003413460.1 NZ_CP095021:2920860-2921300 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T241056 NZ_LT906461:2962840-2963016 [Bordetella hinzii]
GTGAAAACAAGCGAGTTCAGACGGTGGCTCGCTGAACAAGGGGCAACTTTCAAAGAGGGCTCAGCCCACACGAAGGTTTA
CCTGAACGGCAAGCAAACCACCCTGCCACGGCACGGAAGCCAGGAAATAGGCGAAGGACTGAGGCGGGCAATTCTGAAAC
AGCTAGGAATCAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT241056 WP_003413456.1 NZ_CP095021:2920586-2920873 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT241056 NZ_LT906461:2963075-2963491 [Bordetella hinzii]
ATGCTGCGCTACCCCGCAAAGATCGCACCCGATACCGTCGGTTTCATGGTGACTTTCCGCGACATCCCTGAAGCGCTTTC
CGCCGGCCAGACCCGCGAGGAAGCCGAAGCCATGGCCGCTGACGCGCTTCTTGTCGCTATGGACTTCTACTTCGAAGACC
GGCGCCCGGTACCGCCCCCCTCGGCGCCCGTCGGCGACGAGGTAATGATCGCCCTGCCGGCGAGCGCGTCCGCCAAAGTG
CTGCTGCTGAACGAAATGCTCGCCCAGCAGGTCACGCCCAGCGAGTTGGCCAGACGGATGGAAACCCGCAAGCAAGAGGT
AAACAGGATCATTGACTTGAACCACGCCACCAAGATCGACACTATCGCCGCGGCGCTCACCAGCCTCGGCCGCGAACTTG
AACTGACGGTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References