Detailed information of TA system TA241052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2844785..2845425
• Replicon: chromosome
• Accession: NZ_CP095021
• Organism: Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: MUW66_RS13345
• Protein ID: WP_003412970.1
• Coordinates: 2844785..2845204 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: MUW66_RS13350
• Protein ID: WP_003412975.1
• Coordinates: 2845201..2845425 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW66_RS13315 (MUW66_13315)	2840375..2841097	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
MUW66_RS13320 (MUW66_13320)	2841614..2841836	+	223	Protein_2631	type II toxin-antitoxin system VapB family antitoxin	-
MUW66_RS13325 (MUW66_13325)	2841833..2842234	+	402	WP_003412963.1	PIN domain-containing protein	-
MUW66_RS13330 (MUW66_13330)	2842269..2843189	-	921	WP_003412965.1	restriction endonuclease	-
MUW66_RS13335 (MUW66_13335)	2843530..2843775	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
MUW66_RS13340 (MUW66_13340)	2843834..2844784	+	951	WP_003911916.1	ERCC4 domain-containing protein	-
MUW66_RS13345 (MUW66_13345)	2844785..2845204	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW66_RS13350 (MUW66_13350)	2845201..2845425	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
MUW66_RS13355 (MUW66_13355)	2845456..2848299	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
MUW66_RS13360 (MUW66_13360)	2848371..2848772	-	402	WP_003412981.1	hypothetical protein	-
MUW66_RS13365 (MUW66_13365)	2848772..2849242	-	471	WP_003899364.1	transcription antitermination factor NusB	-
MUW66_RS13370 (MUW66_13370)	2849245..2849808	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T241052 WP_003412970.1 NZ_CP095021:c2845204-2844785 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T241052 NZ_LT906460:c2012382-2012017 [Staphylococcus simiae]
ATGATTAAAAGAGGCGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
CATTATACAAAATGATACTGGTAATAAATATAGTCCTACTGTTATTGTGGCGGCAATAACAGGTAGGATAAATAAAGCCA
AAATACCAACACACGTAGAAATTGAAAAAAAGAAATATAAACTTGATAAAGATTCAGTTATTTTACTTGAGCAAATACGA
ACGCTTGATAAGAAACGATTAAAAGAAAAGTTAACGTATTTATCAGAAAGTAAAATGAAGGAAGTAGATAATGCTTTAAT
TATAAGCTTAGGATTAACTACTTTAAGTCAACATAAACTTTCGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT241052 WP_003412975.1 NZ_CP095021:c2845425-2845201 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT241052 NZ_LT906460:c2012549-2012379 [Staphylococcus simiae]
ATGTTATCATTTAGCCAAAATAGAAGTCATAGTTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCAGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTCCCAATAGAGTGCGAAGCATGTGATTGTAATGAATCATATTTATCTTCTAACTCGT
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09