Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2798604..2799256 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag MUW66_RS13150 Protein ID WP_003905869.1
Coordinates 2798831..2799256 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MUW66_RS13145 Protein ID WP_003412749.1
Coordinates 2798604..2798825 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS13130 (MUW66_13130) 2796844..2797050 - 207 WP_003899347.1 hypothetical protein -
MUW66_RS13135 (MUW66_13135) 2797186..2797809 + 624 WP_003900858.1 TIGR00725 family protein -
MUW66_RS13140 (MUW66_13140) 2797799..2798551 + 753 WP_003901416.1 hypothetical protein -
MUW66_RS13145 (MUW66_13145) 2798604..2798825 + 222 WP_003412749.1 antitoxin Antitoxin
MUW66_RS13150 (MUW66_13150) 2798831..2799256 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW66_RS13155 (MUW66_13155) 2799279..2800460 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
MUW66_RS13160 (MUW66_13160) 2800457..2801503 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MUW66_RS13165 (MUW66_13165) 2801514..2802617 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MUW66_RS13170 (MUW66_13170) 2802876..2803697 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MUW66_RS13175 (MUW66_13175) 2803694..2804251 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T241051 WP_003905869.1 NZ_CP095021:2798831-2799256 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T241051 NZ_LT906460:c1850571-1850416 [Staphylococcus simiae]
ATGTTTAATGAAAAAGATGCTAAATCAAATTATCATGAAGATGAAAATGCAATGGTAAATGATTTTGATGATTTGAAAGA
ACTAGGAAAAGAAATGGAACAAATTTCCGAAGAAAACGATCAAGAAAAGCATAATCAATCACACGATAATAATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT241051 WP_003412749.1 NZ_CP095021:2798604-2798825 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT241051 NZ_LT906460:c1851192-1850593 [Staphylococcus simiae]
ATGGCAATGAATTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGACTATGCTGCCGACATTATTAGAAAGCAATTTAA
TAACAACCCAACAACAATAGCTGGGTTTCATTTAGATACAGACCAAGCACCTGTTCTAGATGAATTAAAGAAAAATGTGG
ATCATTATGCAGTGGACTTTAGTCAAATTAATATTTTAGATTATGACAACAATCAATCATATTTTGAAGCTTTAGGAGTA
CCTGAAAGTCAAATTTATGCCATTGGATTTGAAAAAGATGCCATTGAATTTATTTCAGATAAAATTAAAACAAAAGAAAA
TAAAGGTAAATTAACTTTGCAAGTGCTATCTATTAGTGAGCAAGGCAATTTAGATGTTAGTGTGCGTCAAGGATTAATGG
AAGCTAGAGAAATTATTTTAGTCATTACAGGTAGTAATAAACGTGGACTTGTAGAAAAATTATATCAAGAAAATGGTAAA
ACTAGTTATGAGCCAGCTGACTTAAAAGCTCATCGTATGGTTAATGTAATTTTAGATAAAGAAGCTGCTGAAGGCTTACC
AGAAGATGTAAAAACTTACTTTACATCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References