Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402087..2402616 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MUW66_RS11275 Protein ID WP_003411124.1
Coordinates 2402087..2402404 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MUW66_RS11280 Protein ID WP_003411127.1
Coordinates 2402401..2402616 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS11245 (MUW66_11245) 2397108..2398184 + 1077 WP_003411110.1 hypothetical protein -
MUW66_RS11250 (MUW66_11250) 2398181..2398462 + 282 WP_003411112.1 DUF5703 family protein -
MUW66_RS11255 (MUW66_11255) 2398498..2399571 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
MUW66_RS11260 (MUW66_11260) 2399576..2400106 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MUW66_RS11265 (MUW66_11265) 2400154..2401500 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MUW66_RS11275 (MUW66_11275) 2402087..2402404 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUW66_RS11280 (MUW66_11280) 2402401..2402616 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MUW66_RS11285 (MUW66_11285) 2402871..2403929 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
MUW66_RS11290 (MUW66_11290) 2404059..2404415 - 357 WP_003411130.1 hypothetical protein -
MUW66_RS11295 (MUW66_11295) 2404510..2405292 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MUW66_RS11300 (MUW66_11300) 2405560..2405850 - 291 WP_003900476.1 YggT family protein -
MUW66_RS11305 (MUW66_11305) 2406012..2406668 - 657 WP_003411133.1 cell division protein SepF -
MUW66_RS11310 (MUW66_11310) 2406730..2407509 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T241050 WP_003411124.1 NZ_CP095021:c2402404-2402087 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T241050 NZ_LT906460:c1372569-1372474 [Staphylococcus simiae]
ATGTCAATGGTAATTATTAACGTTTTAGGCACGATTATTTCAGGTTGTGCCATTGCTTTTTTCACTTATTGGCTTAATGA
AAAAAGTAAAAAATAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT241050 WP_003411127.1 NZ_CP095021:c2402616-2402401 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT241050 NZ_LT906460:1372390-1372448 [Staphylococcus simiae]
ACATTATAACCATTGACATGGCAAACACAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References