Detailed information of TA system TA241049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2362450..2363145
• Replicon: chromosome
• Accession: NZ_CP095021
• Organism: Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUW66_RS11050
• Protein ID: WP_003905754.1
• Coordinates: 2362450..2362884 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: MUW66_RS11055
• Protein ID: WP_003410814.1
• Coordinates: 2362891..2363145 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW66_RS11040 (MUW66_11040)	2358604..2361645	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
MUW66_RS11045 (MUW66_11045)	2361638..2362471	+	834	WP_003899172.1	SWIM zinc finger family protein	-
MUW66_RS11050 (MUW66_11050)	2362450..2362884	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW66_RS11055 (MUW66_11055)	2362891..2363145	-	255	WP_003410814.1	antitoxin	Antitoxin
MUW66_RS11060 (MUW66_11060)	2363161..2363418	-	258	WP_003410816.1	hypothetical protein	-
MUW66_RS11065 (MUW66_11065)	2363952..2365213	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
MUW66_RS11070 (MUW66_11070)	2365723..2366019	+	297	WP_003410820.1	PE family protein	-
MUW66_RS11075 (MUW66_11075)	2366075..2366782	+	708	Protein_2190	PPE family protein	-
MUW66_RS11080 (MUW66_11080)	2366761..2368022	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T241049 WP_003905754.1 NZ_CP095021:c2362884-2362450 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T241049 NZ_LT906460:277264-277539 [Staphylococcus simiae]
ATGACTAAGTTAAATATCACTTTTTCACCTGATGCCTTTGAAGATTATAAATACTGGCAGAAACAAGATAAAAAGTTATT
GCAAAAGATTAATAGTTTAATTAAAAGTATACAACGTGAAGGTGTACTTGAAGGTGAAGGTAGGCCTGAACCATTACGTG
GTGATTTAAAGAGCTACTATAGTAGAAGAATAAATCATCATGAACATAGAGTGGTATATAAAGTCACAGATTCAGCTATT
TTAATAGCATCATGCCGATACCACTACTATAAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT241049 WP_003410814.1 NZ_CP095021:c2363145-2362891 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT241049 NZ_LT906460:277017-277271 [Staphylococcus simiae]
ATGACTGTTATAACGTATTCAAATGCTAGAAAGAACTTTAGACAGCTTATAGATAATGTCAATGACAATGCTGAAGCTAT
AACGATTACAACTAATGATCGCAATGCCGTCTTACTTTCTGAAGCTGATTACAATTCCATTATGGAAACATTATATTTAC
AGCAATCACCTGCGAATGCTAAACATTTAGCACAATCCATAGCGGATTTAGAACGTGGCAACTCAGTGAAAGTTGATGTT
GAATCTTATGACTAA

Structures

Antitoxin

• AlphaFold DB: G0TMN0