Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2319117..2319753 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag MUW66_RS10855 Protein ID WP_003410654.1
Coordinates 2319343..2319753 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MUW66_RS10850 Protein ID WP_003410651.1
Coordinates 2319117..2319350 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T241048 WP_003410654.1 NZ_CP095021:2319343-2319753 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T241048 NZ_LT906457:c632057-631200 [Legionella spiritensis]
ATGATGAAAGATATCAGTGCTTCTATCCGAGCACGACTAAAAAATATCGCGAAAGAAGAACAAACTGACTTCAATGCAGT
ATTAACCCGTTATGGTCTTGAGCGTTTGCTATACCGAATTGGTCAATCTGAATATGCCAATCAATATTTATTGAAAGGTG
CTTTACTATTTAACTTATGGTACGACATGCCACATCGACCTACTTTGGATATTGACTTGTTAGGATTTGGTAATAACGAA
CTTGATTATTTGACAGGTGTTTTCAAAGAAATTTGCATAATTTCTGCTGCTGATGGAATCATTTTTGATGAGAAATCTGT
TTCAGCAAATACTATAAAAAAAGAGGGTGGATATACAGGTGCCAGAATCGAGTTATTTGCTGAATTGTCAAAGGCACGTA
TTAAAATACAAATTGATATTGGTTATGGTGATGTTGTAACGCCCGGCCCAATTGATTTGAATTATCCTGTTTTGATAAGT
GATCTACCTCCGCCAAAAATTCGAACCTATCCAATTTATACAGTGATTGCTGAAAAGCTGCATGCAATTGCCTTATTGGG
TATGGCAAATAGTCGATTAAAAGATTATCTGGATCTATATGTATTATTGAAAAATGAAGAACTAGACGAAGAAACAGTGA
TAGATGCTATCATTTCTACCTTCACTCAAAGAGGGATGACTATTCCTAAAAATCTACCAATTGGTTTGACCTCAGAATAT
AGTCAGGATGGATCGAGACAAGCAATGTGGAATTCTTTCTTAAATAAAAATGAAGTTGAACTCAAACCGTTGCCAGAGGC
CGTGTCTTCGATAGGAGATTATATCCAGCCAATTCTTGTTAAAGCTTCTACAAGATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT241048 WP_003410651.1 NZ_CP095021:2319117-2319350 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT241048 NZ_LT906457:c632662-632054 [Legionella spiritensis]
ATGAATGCAGAGAAAAATTATAAACAAACAGTTCTCAATATGGTTAGAGAAAAGGGAATTATTAAAATTTCTGAGCTAAC
CAAAAAGGGAATAACCAGAGCGACAGTTTCAAGGCTTGTAAGCGAAAACAAACTTGAAAAAATTGCAACAGGACTCTATT
GTCTACCAGAAACTGAGTTCTCAGAAAAAGAAAGTCTAGTTATTCTAGCAAGCCGAGTACCGCAAGCAGTATTTTGTCTA
CTAACAGCCCTGCAAATTCATGAGCTAACAACGCAACTACCACGAAAGGTTTGGATTGCAATGCCTAGAGGTAGTCACAC
ACCAAAGATTGATTATCCCCCTGTGAAAATGATTCAGTACTCAAAAGAAGTTTATGAAGAAGGTATTGAAACAATAGAAT
CAGATAATATTAAATTGAGAGTTTACAATTCTGCCAAAACAATAGCTGATTGCTTTAAGCACCGTACAACAATTGGTATT
GATGTAGCTATTGAAGCACTAAAAGAAGCGTATTCAAAAAACAAAGTTTCAATGGATGAGCTATGGCATTATGCGAAAAT
ATGTCGTGTTGCCAATATAATGCGTCCTTATCTAGAAGCTATCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References