Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2226871..2227457 | Replicon | chromosome |
| Accession | NZ_CP095021 | ||
| Organism | Mycobacterium tuberculosis strain SGF0422017 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | MUW66_RS10450 | Protein ID | WP_003410010.1 |
| Coordinates | 2226871..2227215 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | MUW66_RS10455 | Protein ID | WP_003410014.1 |
| Coordinates | 2227209..2227457 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW66_RS10415 (MUW66_10415) | 2222577..2223176 | + | 600 | WP_003910883.1 | L-lysine exporter | - |
| MUW66_RS10420 (MUW66_10420) | 2223592..2224020 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| MUW66_RS10425 (MUW66_10425) | 2224246..2224785 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| MUW66_RS10430 (MUW66_10430) | 2225305..2225865 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| MUW66_RS10435 (MUW66_10435) | 2225862..2226203 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| MUW66_RS10440 (MUW66_10440) | 2226289..2226546 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| MUW66_RS10445 (MUW66_10445) | 2226447..2226782 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| MUW66_RS10450 (MUW66_10450) | 2226871..2227215 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| MUW66_RS10455 (MUW66_10455) | 2227209..2227457 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| MUW66_RS10460 (MUW66_10460) | 2227557..2229872 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| MUW66_RS10465 (MUW66_10465) | 2229869..2230141 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| MUW66_RS10470 (MUW66_10470) | 2230194..2230550 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| MUW66_RS10475 (MUW66_10475) | 2230707..2231054 | + | 348 | Protein_2070 | hemerythrin domain-containing protein | - |
| MUW66_RS10480 (MUW66_10480) | 2231054..2231887 | + | 834 | Protein_2071 | universal stress protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T241045 WP_003410010.1 NZ_CP095021:c2227215-2226871 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T241045 NZ_LT906456:c2047025-2046663 [Actinobacillus suis]
GTGAAGTTAGTTTTTGTAGAATTACCACCTTTTGAGCGATATAGACAAAAGCACCTTAGTGATGAAGAATATAGACATTT
TCAGAATGAGCTATTAGAAAATCCTAATAAAGGAGATTTAATCCAAGGTACGAACGGCTTACGCAAAATTAGAATTGCAG
ATATGCAACGAAATAAAGGTAAGAGAGGTGGAGCAAGGGTAATTTATTATCATATTGTGAATTATTCAAAAATTTTGTTG
GTTACCGCATATGGTAAAGATGAACAATCAGATTTATCTAATACGGAACGCAATATGTTAGCGAATAAAGTGAAGCGTAT
TGTTGAATTAGAGATAAGGAGTAGTAATGGGAAAACTTTTTGA
GTGAAGTTAGTTTTTGTAGAATTACCACCTTTTGAGCGATATAGACAAAAGCACCTTAGTGATGAAGAATATAGACATTT
TCAGAATGAGCTATTAGAAAATCCTAATAAAGGAGATTTAATCCAAGGTACGAACGGCTTACGCAAAATTAGAATTGCAG
ATATGCAACGAAATAAAGGTAAGAGAGGTGGAGCAAGGGTAATTTATTATCATATTGTGAATTATTCAAAAATTTTGTTG
GTTACCGCATATGGTAAAGATGAACAATCAGATTTATCTAATACGGAACGCAATATGTTAGCGAATAAAGTGAAGCGTAT
TGTTGAATTAGAGATAAGGAGTAGTAATGGGAAAACTTTTTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT241045 WP_003410014.1 NZ_CP095021:c2227457-2227209 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT241045 NZ_LT906456:c2046679-2046371 [Actinobacillus suis]
ATGGGAAAACTTTTTGATGATTTAATGGAAGGGCTTGATGCTTATGAAAAACATATCCAAGGCAAAATCACCCTGCGAAC
CACGGTATTAGAAAAGCCTGAACCAGTAGAACTTAGCCCGTCTGAAGTTAAATTGATTCGAGAAAAATTAAATCTGTCGC
AAGCGGTTTTTGCGCATAAATTGCATACTTCCGTGCGGACTTATCAAGGGTGGGAGCAAGGCAAAACCAAACCGAATCCA
CAAGCGGTACTGTTGCTTCGTATGGTGGATAAATCGCCTCAGTTATTAGAACAAATGGCACAGCTCTAA
ATGGGAAAACTTTTTGATGATTTAATGGAAGGGCTTGATGCTTATGAAAAACATATCCAAGGCAAAATCACCCTGCGAAC
CACGGTATTAGAAAAGCCTGAACCAGTAGAACTTAGCCCGTCTGAAGTTAAATTGATTCGAGAAAAATTAAATCTGTCGC
AAGCGGTTTTTGCGCATAAATTGCATACTTCCGTGCGGACTTATCAAGGGTGGGAGCAAGGCAAAACCAAACCGAATCCA
CAAGCGGTACTGTTGCTTCGTATGGTGGATAAATCGCCTCAGTTATTAGAACAAATGGCACAGCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|