Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2225305..2226203 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MUW66_RS10430 Protein ID WP_003410001.1
Coordinates 2225305..2225865 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MUW66_RS10435 Protein ID WP_003410003.1
Coordinates 2225862..2226203 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS10400 (MUW66_10400) 2220474..2221127 - 654 WP_003409976.1 cutinase Cfp21 -
MUW66_RS10405 (MUW66_10405) 2221242..2221472 + 231 WP_003409980.1 DUF167 domain-containing protein -
MUW66_RS10410 (MUW66_10410) 2221557..2222468 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MUW66_RS10415 (MUW66_10415) 2222577..2223176 + 600 WP_003910883.1 L-lysine exporter -
MUW66_RS10420 (MUW66_10420) 2223592..2224020 + 429 WP_003409992.1 cellulose-binding protein -
MUW66_RS10425 (MUW66_10425) 2224246..2224785 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MUW66_RS10430 (MUW66_10430) 2225305..2225865 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MUW66_RS10435 (MUW66_10435) 2225862..2226203 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MUW66_RS10440 (MUW66_10440) 2226289..2226546 + 258 WP_003410006.1 hypothetical protein -
MUW66_RS10445 (MUW66_10445) 2226447..2226782 - 336 WP_003410009.1 dehydrogenase -
MUW66_RS10450 (MUW66_10450) 2226871..2227215 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MUW66_RS10455 (MUW66_10455) 2227209..2227457 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MUW66_RS10460 (MUW66_10460) 2227557..2229872 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MUW66_RS10465 (MUW66_10465) 2229869..2230141 - 273 WP_003410017.1 DUF1490 family protein -
MUW66_RS10470 (MUW66_10470) 2230194..2230550 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
MUW66_RS10475 (MUW66_10475) 2230707..2231054 + 348 Protein_2070 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T241044 WP_003410001.1 NZ_CP095021:c2225865-2225305 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T241044 NZ_LT906456:c1931463-1930996 [Actinobacillus suis]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCAACATTTTCAATGCGGTGAGGTCGTACTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACTTTTGTTGTGTGTGATGAGAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGTCGTCAGTTTGTTGCAGGCGCATTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGCTCAGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAGTCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT241044 WP_003410003.1 NZ_CP095021:c2226203-2225862 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT241044 NZ_LT906456:c1931727-1931467 [Actinobacillus suis]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGTATTTTAGGTAA
GACACGTTCTGACTTTATGTTAGAAACCGCATGCCAAGCTGCCCAAAATGTGATTTTAGATCGCACTGTTTTCCAATTAA
ATGAGCAGACTTTTGAGCAATTTAACCGATTGCTAGAACAACCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References