Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2217979..2218667 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MUW66_RS10385 Protein ID WP_003409958.1
Coordinates 2217979..2218398 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MUW66_RS10390 Protein ID WP_003409968.1
Coordinates 2218407..2218667 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS10365 (MUW66_10365) 2213474..2214322 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
MUW66_RS10370 (MUW66_10370) 2214285..2215730 - 1446 WP_003899115.1 APC family permease -
MUW66_RS10375 (MUW66_10375) 2215909..2216595 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MUW66_RS10380 (MUW66_10380) 2216786..2217754 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MUW66_RS10385 (MUW66_10385) 2217979..2218398 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW66_RS10390 (MUW66_10390) 2218407..2218667 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW66_RS10395 (MUW66_10395) 2218810..2220486 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
MUW66_RS10400 (MUW66_10400) 2220474..2221127 - 654 WP_003409976.1 cutinase Cfp21 -
MUW66_RS10405 (MUW66_10405) 2221242..2221472 + 231 WP_003409980.1 DUF167 domain-containing protein -
MUW66_RS10410 (MUW66_10410) 2221557..2222468 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MUW66_RS10415 (MUW66_10415) 2222577..2223176 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T241043 WP_003409958.1 NZ_CP095021:c2218398-2217979 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T241043 NZ_LT906456:c1273935-1273591 [Actinobacillus suis]
ATGAATTCTGATGAATATTTAACCTTTGTTGAGGTTGGTACATTCGAGGAAGATCGTAAGCAATTAATGGCAGACGATGA
GTACCAATTATTCCAAGCATATTTATTAGAGCATTACGAATTAGGGGATTTTATTTCCCATACAGGTGGTTGCCAAAAGA
TCAGGTGGCGCTTACCGGAAAATAATAAGGGGAAAAGTGCTGGTGTTCGAATTATCTATTATGTTAGAAGTTTAACAGGG
CGAATTTACCTAATTACTATGTATGGAAAAAGCGAAAAAGTTAATCTAAATGCTCGAGAAAAAGCGATTATGAAGAAAAT
TATTTCGAGATTAATAGGAGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT241043 WP_003409968.1 NZ_CP095021:c2218667-2218407 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT241043 NZ_LT906456:c1273586-1273290 [Actinobacillus suis]
ATGGAAAAACGTTTATTTGAGCGCCTTGTACAAGGATTAGAAGAAATGGTTGCTATTGAAAAAGGTGAGGTGGAAGTACC
ATCGCATCGCATCCATGCACATAAAATTCCAAATACTAAGGCGATTCGTACACAACACCATTTGAAACAGGCAGAATTTG
CACAGCTGTTAGGTGTCAGTACCAATTTGGTGCAATCTTGGGAAATCGGCAGACGAGTCCCTAATGGAGCGGCAAGAAAA
TTATTGGCGATTATCGAACAACAACCGAATTTAGTCCCTTTGCTACAATCTCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References