Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1942731..1943344 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MUW66_RS09055 Protein ID WP_003408465.1
Coordinates 1942731..1943120 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MUW66_RS09060 Protein ID WP_003408469.1
Coordinates 1943117..1943344 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS09020 (MUW66_09020) 1938360..1939274 + 915 WP_244743783.1 3-hydroxyacyl-CoA dehydrogenase family protein -
MUW66_RS09025 (MUW66_09025) 1939277..1940107 + 831 WP_003408448.1 cyclase family protein -
MUW66_RS09030 (MUW66_09030) 1940107..1940457 + 351 WP_003898986.1 cupin domain-containing protein -
MUW66_RS09035 (MUW66_09035) 1940510..1941328 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MUW66_RS09040 (MUW66_09040) 1941342..1942121 + 780 WP_003408460.1 IclR family transcriptional regulator -
MUW66_RS09050 (MUW66_09050) 1942552..1942683 + 132 Protein_1784 IS3 family transposase -
MUW66_RS09055 (MUW66_09055) 1942731..1943120 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW66_RS09060 (MUW66_09060) 1943117..1943344 - 228 WP_003408469.1 antitoxin Antitoxin
MUW66_RS09065 (MUW66_09065) 1943562..1945046 + 1485 WP_003408473.1 biotin carboxylase -
MUW66_RS09070 (MUW66_09070) 1945043..1946290 + 1248 WP_003408476.1 serine hydrolase -
MUW66_RS09075 (MUW66_09075) 1946333..1946752 - 420 WP_003408483.1 hypothetical protein -
MUW66_RS09080 (MUW66_09080) 1946742..1947452 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T241038 WP_003408465.1 NZ_CP095021:c1943120-1942731 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T241038 NZ_LT906454:c1216422-1216159 [Streptococcus acidominimus]
ATGATTTATCAGGTAAGGTTGACTTCGAAAGCAGACAAACAGCTTAGAAAATTAGATGCCTATACCCGAAATACCATCTT
GGCATGGATTAAGAAAAACCTTTACCAGACAGACAATCCTCGTCTACATGGCAAGGGGCTCACAGCTAATCACTCAGGTG
AGTGGCGCTACCGTGTTGGTAATTACCGCATTTTAGCGAACATTTATGATGATGAGATTGTGATTGAGATTTTTACAATC
GGTCATCGTCGAGATATTTATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT241038 WP_003408469.1 NZ_CP095021:c1943344-1943117 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT241038 NZ_LT906454:c1216634-1216419 [Streptococcus acidominimus]
ATGACTACGATGACATTACGTATCAATGATGAGGATTCGAACCTTATTAAGAACTATATTAAGCTTCACGGATTATCTAT
TTCTGAGTTTGCACGCCAATCAATGCTCGAACGTATTGAAGATGAGTACGATTTAGCTGTTTTACGTCAGGCTATGTCTG
AGGATGATAGTATTAGAATCCCAGTGGAGGATCTTTTTGAGGAATTCGGCATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References