Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1576962..1577617 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag MUW66_RS07445 Protein ID WP_003898861.1
Coordinates 1576962..1577363 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MUW66_RS07450 Protein ID WP_003407272.1
Coordinates 1577360..1577617 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS07430 (MUW66_07430) 1572434..1573819 - 1386 WP_003407260.1 cytochrome P450 -
MUW66_RS07435 (MUW66_07435) 1573897..1574931 + 1035 WP_003407264.1 AraC family transcriptional regulator -
MUW66_RS07440 (MUW66_07440) 1574977..1576707 - 1731 WP_009940170.1 PE family protein -
MUW66_RS07445 (MUW66_07445) 1576962..1577363 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW66_RS07450 (MUW66_07450) 1577360..1577617 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
MUW66_RS07455 (MUW66_07455) 1577700..1578659 - 960 WP_003407276.1 alpha/beta hydrolase -
MUW66_RS07460 (MUW66_07460) 1578684..1579646 - 963 WP_003905554.1 alpha/beta hydrolase -
MUW66_RS07465 (MUW66_07465) 1579645..1580382 + 738 WP_031647000.1 lysoplasmalogenase -
MUW66_RS07470 (MUW66_07470) 1580463..1582430 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T241035 WP_003898861.1 NZ_CP095021:c1577363-1576962 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T241035 NZ_LT906452:c68593-67289 [Legionella pneumophila]
ATGGTAATGCGTAAATTATACATATTAATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAACCACATTCGCGACCTGTATCTTTATCGTTGCCGTTAGTAAATCAAAGGT
TTTCAGGAGAAGTTGTATATAACTTTTTTGATAACTTACTTCCTGATAATCCGCAGATAAGAGCCAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGCCTCAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGCTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGAGGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCTGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAAT
TTTTCAGAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAACTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT241035 WP_003407272.1 NZ_CP095021:c1577617-1577360 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT241035 NZ_LT906452:c68826-68587 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAACGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References