Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1541239..1542289 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag MUW66_RS07285 Protein ID WP_003407164.1
Coordinates 1541239..1542060 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag MUW66_RS07290 Protein ID WP_003407167.1
Coordinates 1542053..1542289 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS07265 (MUW66_07265) 1536797..1537459 - 663 WP_003407152.1 membrane protein -
MUW66_RS07270 (MUW66_07270) 1537456..1538241 - 786 WP_003407157.1 membrane protein -
MUW66_RS07275 (MUW66_07275) 1538532..1540493 - 1962 WP_003407159.1 sigma-F factor regulator -
MUW66_RS07280 (MUW66_07280) 1540632..1541018 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
MUW66_RS07285 (MUW66_07285) 1541239..1542060 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
MUW66_RS07290 (MUW66_07290) 1542053..1542289 + 237 WP_003407167.1 hypothetical protein Antitoxin
MUW66_RS07295 (MUW66_07295) 1542361..1543566 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
MUW66_RS07300 (MUW66_07300) 1543869..1544654 + 786 WP_003902048.1 lipoprotein LprF -
MUW66_RS07305 (MUW66_07305) 1544850..1545464 + 615 Protein_1437 cytochrome b5-like heme/steroid binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T241034 WP_003407164.1 NZ_CP095021:1541239-1542060 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T241034 NZ_LT906451:1998190-1998444 [Legionella lansingensis]
ATGATTTTATCATGGGCTGAAAATGCATGGGAAGATTATCTTTATTGGCAAGCAACTGATAAAAAAATGATTAAACGGAT
TAATGCCCTTATAAAAGACATTCAACGACATCCCTTCGATGGAATAGGTGACCCAGAGCCCTTGAAACATCATTGGTCCG
GGTATTGGTCACGTCGAATTGATAGAGAACATCGAATTATCTACAAAGCAACCGATGAGGCTCTTTATATTGTGCAATGT
CGATATCACTATTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT241034 WP_003407167.1 NZ_CP095021:1542053-1542289 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT241034 NZ_LT906451:1997939-1998193 [Legionella lansingensis]
ATGGACGTTTTAAGTTACTCCGCTTTAAGAAATAATTTGGCAAGTATTTTAGATAAAGTAAATGAAGATCATGTTTCTAT
ACTAATCACCAGACAAAATGGAAAACCAGCAGTCATTATGTCTTTGGAAGACTTCAAATCTTATGAAGAAACAGCTTATT
TAATGTCAAGCCCGAAAAATGTAGAACGTTTAAATCAAGCAATAGCCGAAGTAGAGGCCGGAAAAACAAAAGAACATGGA
ATTATTGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References